Value of TRAcP 5b as a diagnostic marker for detection of bone metastases in patients with breast cancer.

Abstract

BACKGROUND/AIMS:

The aim of the study was to test the bone resorption marker TRAcP 5b regarding its suitability for detection of bone metastases in breast cancer patients.

PATIENTS AND METHODS:

Serum samples from a total of 101 patients with histologically proven breast cancer and from 100 healthy probands were analyzed. The patients were divided into three groups: eight patients without osseous involvement, 65 patients with untreated bone metastases, 28 patients whose bone metastases were treated with bisphosphonate therapy.

RESULTS:

The TRAcP 5b concentration was significantly higher in breast cancer patients compared to healthy probands. It was not possible to demonstrate a statistically significant difference in the TRAcP 5b concentration if osseous metastases in breast cancer patients were present or not.

CONCLUSION:

Our research cannot support the claim that TRAcP 5b could be useful as a diagnostic tool for the detection of bone metastases in patients with breast cancer.

• Authors: M J Hung, G M Oremek
• Journal: European journal of gynaecological oncology (Eur J Gynaecol Oncol) Vol. 32 Issue 6 Pg. 615-8 ( 2011) ISSN: 0392-2936 [Print] Singapore
• PMID: 22335021 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Carcinoembryonic Antigen
• Isoenzymes
• Mucin-1
• ACP5 protein, human
• Acid Phosphatase
• Tartrate-Resistant Acid Phosphatase

Topics

• Acid Phosphatase (analysis)
• Adult
• Aged
• Biomarkers, Tumor (analysis)
• Bone Neoplasms (diagnosis, secondary)
• Breast Neoplasms (chemistry, pathology)
• Carcinoembryonic Antigen (analysis)
• Female
• Humans
• Isoenzymes (analysis)
• Male
• Middle Aged
• Mucin-1 (blood)
• ROC Curve
• Tartrate-Resistant Acid Phosphatase