[Effectiveness of anti-TNF alpha antibodies in treatment of fistulizing Crohn's disease].

Abstract

INTRODUCTION:

About 35% of patients with Crohn's disease develop fistulae. Treatment of those changes is a complicated clinical problem. Anti-TNF alpha antibodies are currently the most effective therapy of fistulizing Crohn's disease. Aim of the study is to evaluate results of anti-TNF alpha treatment in patients with fistulizing Crohn's disease.

METHODS:

We evaluated results of anti-TNF alpha treatment (both with adalimumab n=10 and infliximab n=19) in 29 patients with fistulizing Crohn's disease treated in years 2008 - 2011 in Gastroenterology and Hepatology Clinic of University Hospital in Krakow.

RESULTS:

Closure of over 50% of fistulas was achieved by 78,94% patients after induction therapy with infliximab and 50% with adalimumab. Long term remission, evaluated after 52 weeks of treatment, was observed in 46,15% patients treated with infliximab. Best results were observed in perianal fistulas treatment - remission was achieved in 88.2% of patients. Effectiveness of enterocutaneus fistalas therapy was lower, and their healing was observed in 28.57% of patients. We observed no correlation between duration of Crohn's disease, duration of fistulas history or previously used treatment and results of anti-TNF alpha treatment.

CONCLUSIONS:

Anti-TNF alpha treatment has high effectiveness both short and long term in fistulizing Crohn's disease. Tolerance of treatment is very good. We lack clinical data about treatment other fistulas than perianal, but we suspect that effectiveness of anti-TNF alpha in this cases is lower. It is indicated to treat patients with fistulizing Crohn's disease with anti-TNF alpha, because it gives them chance for long remission and improvement of quality of life.

• Authors: Piotr Rozpondek, Małgorzata Zwolińska-Wcisło, Magdalena Przybylska, Tomasz Mach
• Journal: Przeglad lekarski (Przegl Lek) Vol. 68 Issue 9 Pg. 602-5 ( 2011) ISSN: 0033-2240 [Print] Poland
• Vernacular Title: Skuteczność leczenia przetok w przebiegu choroby Leśniowskiego-Crohna przeciwciałami anty-TNF alpha.
• PMID: 22335009 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Tumor Necrosis Factor-alpha
• Infliximab
• Adalimumab

Topics

• Adalimumab
• Adult
• Aged
• Anti-Inflammatory Agents (therapeutic use)
• Antibodies, Monoclonal (therapeutic use)
• Antibodies, Monoclonal, Humanized (therapeutic use)
• Crohn Disease (complications, drug therapy)
• Female
• Humans
• Infliximab
• Intestinal Fistula (drug therapy, etiology)
• Male
• Middle Aged
• Quality of Life
• Remission Induction
• Tumor Necrosis Factor-alpha (immunology)
• Young Adult