[A 17-year study of bloodstream Escherichia coli infection after liver transplantation: resistance rate, risk factor and mortality].

Abstract

OBJECTIVE:

To explore the resistance rate, risk factors and mortality of Escherichia coli bloodstream infections (BSI) after liver transplantation.

METHODS:

From January 1993 to May 2010, a retrospective analysis of Escherichia coli in liver transplants were conducted.

RESULTS:

A total of 88 BSI occurred in 83/695 patients and Escherichia coli (n = 23) was most commonly found. Carbapenem and piperacillin-tazobactam were the most consistently active against Escherichia coli while the resistance rate to enterococcus for ciprofloxacin, gentamycin, ampicillin-clavulanic acid was over 60%. Univariate analysis identified the following variables as risk factors for Escherichia coli bacteremia: cholangioenterostomy (P < 0.001) and ductal complications (P < 0.001). Escherichia coli bloodstream infection could increase the mortality at 15 days after bloodstream infection. No significant difference in mortality occurred at 30 days and 1 year after enterococcal bacteremia.

CONCLUSION:

Escherichia coli after liver transplantation is resistant to agents but commonly active to carbapenem and piperacillin-tazobactam. The risk factor associated with Escherichia coli bloodstream infections are cholangioenterostomy and ductal complications. Escherichia coli bloodstream infection can increase the mortality at 15 days after bloodstream infection.

• Authors: Qiang Tai, Xiao-shun He, An-bin Hu, Lin-wei Wu, Wei-qiang Ju, Xiao-feng Zhu, Dong-ping Wang, Guo-dong Wang, Yi Ma, Zhi-yong Guo, Jie-fu Huang
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 91 Issue 42 Pg. 2977-80 (Nov 15 2011) ISSN: 0376-2491 [Print] China
• PMID: 22333023 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents

Topics

• Anti-Bacterial Agents (pharmacology)
• Bacteremia (etiology, mortality)
• Drug Resistance, Bacterial
• Escherichia coli (drug effects)
• Escherichia coli Infections (etiology, mortality)
• Female
• Humans
• Liver Transplantation (adverse effects)
• Male
• Retrospective Studies
• Risk Factors
• Survival Rate