Abstract | OBJECTIVE: METHODS: We calculated dietary intake from questionnaires completed annually by 357 adult patients from 3 randomized trials who were all receiving vitamin A, 15 000 IU/d, for 4 to 6 years. Rates of visual acuity decline were compared between those with high (≥0.20 g/d) vs low (<0.20 g/d) ω-3 intake. Analyses took age into account. RESULTS: Mean rates of decline of acuity were slower among those with high ω-3 intake: Early Treatment Diabetic Retinopathy Study distance acuity: high intake=0.59 letter per year, low intake=1.00 letter per year,P=.001; Snellen retinal acuity: high intake=1.5% per year, low intake=2.8% per year, P=.03. CONCLUSIONS: We conclude that mean annual rates of decline in distance and retinal visual acuities in adults with retinitis pigmentosa receiving vitamin A, 15 000 IU/d,are slower over 4 to 6 years among those consuming a diet rich in ω-3 fatty acids. To our knowledge, this is the first report that nutritional intake can modify the rate of decline of visual acuity in retinitis pigmentosa.
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Authors | Eliot L Berson, Bernard Rosner, Michael A Sandberg, Carol Weigel-DiFranco, Walter C Willett |
Journal | Archives of ophthalmology (Chicago, Ill. : 1960)
(Arch Ophthalmol)
Vol. 130
Issue 6
Pg. 707-11
(Jun 2012)
ISSN: 1538-3601 [Electronic] United States |
PMID | 22332205
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Diterpenes
- Fatty Acids, Omega-3
- Phosphatidylethanolamines
- Retinyl Esters
- Vitamin A
- retinol palmitate
- Docosahexaenoic Acids
- phosphatidylethanolamine
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Topics |
- Adolescent
- Adult
- Antioxidants
(administration & dosage)
- Diet
- Diterpenes
- Docosahexaenoic Acids
(metabolism)
- Erythrocyte Membrane
(metabolism)
- Fatty Acids, Omega-3
(administration & dosage)
- Feeding Behavior
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Nutrition Surveys
- Phosphatidylethanolamines
(metabolism)
- Retinitis Pigmentosa
(diet therapy, physiopathology)
- Retinyl Esters
- Surveys and Questionnaires
- Vision Disorders
(diet therapy, physiopathology)
- Visual Acuity
(physiology)
- Visual Fields
(physiology)
- Vitamin A
(administration & dosage, analogs & derivatives)
- Young Adult
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