Protective activity of processed tomato products on postprandial oxidation and inflammation: a clinical trial in healthy weight men and women.

Abstract

SCOPE:

This study was designed to evaluate the ability of tomato rich in lycopene to modify postprandial oxidative stress, inflammation, and endothelial function in healthy weight individuals.

METHODS AND RESULTS:

Twelve women and 13 men (mean age = 27 ± 8 years; mean body mass index= 22 ± 2) consumed high-fat meals known to induce postprandial oxidative stress on two separate occasions containing either processed tomato product or non-tomato alternative. Blood samples were collected at 0, 30, 60, 90, 120 min, then hourly until 360 min. Flow-mediated dilation (FMD) was performed at 0 and 210 min. Endpoints included changes in glucose, insulin, lipids, oxidized low-density lipoprotein (OxLDL), inflammatory cytokines, and FMD. Both meals induced increases in plasma glucose, insulin, and lipid concentrations (p < 0.05). A trend for higher triglycerides at >240 min was observed after the tomato meal (p = 0.006). Tomato significantly attenuated high-fat meal-induced LDL oxidation (p < 0.05) and rise in interleukin-6 (p < 0.0001), a proinflammatory cytokine and inflammation marker.

CONCLUSION:

The data indicate that consuming tomato products with a meal attenuates postprandial lipemia-induced oxidative stress and associated inflammatory response. The relevance of OxLDL and inflammation to vascular injury suggests a potentially important protective role of tomato in reducing cardiovascular disease risk. ClinicalTrials.gov Registration number - NCT00966550.

• Authors: Britt Burton-Freeman, Julie Talbot, Eunyoung Park, Sandhya Krishnankutty, Indika Edirisinghe
• Journal: Molecular nutrition & food research (Mol Nutr Food Res) Vol. 56 Issue 4 Pg. 622-31 (Apr 2012) ISSN: 1613-4133 [Electronic] Germany
• PMID: 22331646 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Blood Glucose
• Insulin
• Interleukin-6
• Lipoproteins, LDL
• oxidized low density lipoprotein

Topics

• Adult
• Blood Glucose (analysis)
• Cross-Over Studies
• Endothelium, Vascular (drug effects, physiopathology)
• Endpoint Determination
• Female
• Humans
• Hyperlipidemias (physiopathology, therapy)
• Inflammation (physiopathology, prevention & control)
• Insulin (blood)
• Interleukin-6 (blood)
• Lipoproteins, LDL (blood)
• Solanum lycopersicum (chemistry)
• Male
• Oxidation-Reduction
• Oxidative Stress (drug effects)
• Postprandial Period (drug effects)
• Young Adult