The tick salivary protein sialostatin L inhibits the Th9-derived production of the asthma-promoting cytokine IL-9 and is effective in the prevention of experimental asthma.
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| Abstract |
Ticks developed a multitude of different immune evasion strategies to obtain a blood meal. Sialostatin L is an immunosuppressive cysteine protease inhibitor present in the saliva of the hard tick Ixodes scapularis. In this study, we demonstrate that sialostatin L strongly inhibits the production of IL-9 by Th9 cells. Because we could show recently that Th9-derived IL-9 is essentially involved in the induction of asthma symptoms, sialostatin L was used for the treatment of experimental asthma. Application of sialostatin L in a model of experimental asthma almost completely abrogated airway hyperresponsiveness and eosinophilia. Our data suggest that sialostatin L can prevent experimental asthma, most likely by inhibiting the IL-9 production of Th9 cells. Thus, alternative to IL-9 neutralization sialostatin L provides the basis for the development of innovative therapeutic strategies to treat asthma.
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| Authors | Helena Horka, Valérie Staudt, Matthias Klein, Christian Taube, Sebastian Reuter, Nina Dehzad, John F Andersen, Jan Kopecky, Hansjörg Schild, Michalis Kotsyfakis, Markus Hoffmann, Bastian Gerlitzki, Michael Stassen, Tobias Bopp, Edgar Schmitt |
| Journal | Journal of immunology (Baltimore, Md. : 1950) (J Immunol) Vol. 188 Issue 6 Pg. 2669-76 (Mar 15 2012) ISSN: 1550-6606 [Electronic] United States |
| PMID | 22327077 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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