Abstract | BACKGROUND: METHODS: RESULTS: During more than 8 years of follow-up, all-cause mortality occurred in 75% and 79% of matched patients with chronic kidney disease receiving and not receiving angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, respectively (hazard ratio [HR], 0.86; 95% confidence interval [CI], 0.74-0.996; P=.045). There was no significant association with heart failure hospitalization (HR, 0.86; 95% CI, 0.72-1.03; P=.094). Similar mortality reduction (HR, 0.83; 95% CI, 0.70-1.00; P=.046) occurred in a subgroup of matched patients with estimated glomerular filtration rate less than 45 mL/min/1.73 m(2). Among 171 pairs of propensity-matched patients without chronic kidney disease, the use of these drugs was associated with a significant reduction in all-cause mortality (HR, 0.72; 95% CI, 0.55-0.94; P=.015) and heart failure hospitalization (HR, 0.71; 95% CI, 0.52-0.95; P=.023). CONCLUSION:
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Authors | Ali Ahmed, Gregg C Fonarow, Yan Zhang, Paul W Sanders, Richard M Allman, Donna K Arnett, Margaret A Feller, Thomas E Love, Inmaculada B Aban, Raynald Levesque, O James Ekundayo, Louis J Dell'Italia, George L Bakris, Michael W Rich |
Journal | The American journal of medicine
(Am J Med)
Vol. 125
Issue 4
Pg. 399-410
(Apr 2012)
ISSN: 1555-7162 [Electronic] United States |
PMID | 22321760
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | Published by Elsevier Inc. |
Chemical References |
- Angiotensin Receptor Antagonists
- Angiotensin-Converting Enzyme Inhibitors
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Topics |
- Aged
- Aged, 80 and over
- Alabama
(epidemiology)
- Angiotensin Receptor Antagonists
(therapeutic use)
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Female
- Heart Failure, Systolic
(complications, drug therapy, mortality)
- Hospitalization
(statistics & numerical data)
- Humans
- Male
- Renal Insufficiency, Chronic
(complications, drug therapy, mortality)
- Renin-Angiotensin System
- Treatment Outcome
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