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Protective Effects of Platycodon grandiflorum Aqueous Extract on Thioacetamide-induced Fulminant Hepatic Failure in Mice.

Abstract
The aim of the present study was to evaluate the protective activity of aqueous extract from Platycodon grandiflorum (BC703) on thioacetamide (TA)-induced hepatotoxicity in mice. We found that BC703 significantly decreased mortality and the change in serum transaminase following TA administration. The group treated with BC703 at doses of 1, 5, and 10 mg/kg produced significant hepatoprotective effects against TA-induced liver damage by decreasing the activities of serum enzymes, nitric oxide and lipid peroxidation in dose-dependent manners. Histopathological studies further substantiated the protective effect of BC703. These results show the hepatoprotective activity of aqueous extract from Platycodon grandiflorum on thioacetamide-induced fulminant hepatic failure.
AuthorsJong-Hwan Lim, Tae-Won Kim, Sang-Jin Park, In-Bae Song, Myoung-Seok Kim, Hyo-Jung Kwon, Eun-Sang Cho, Hwa-Young Son, Sang-Wook Lee, Joo-Won Suh, Jong-Woo Kim, Hyo-In Yun
JournalJournal of toxicologic pathology (J Toxicol Pathol) Vol. 24 Issue 4 Pg. 223-8 (Dec 2011) ISSN: 1881-915X [Electronic] Japan
PMID22319234 (Publication Type: Journal Article)

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