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Vertical administration of vanadium through lactation induces behavioural and neuromorphological changes: protective role of vitamin E.

Abstract
The work investigated the protective role of vitamin E on vanadium induced neurotoxicity. Three adult female rats were divided into three groups, A-C with each dam and her pups forming a group. Group A served as control. The dam in Group B was given 3mg/kg b.w./day of vanadium from PND 1 while the Group C dam were given 3mg/kg b.w./day of vanadium, for 14 days and 500mg/kg b.w. of vitamin E 72 hourly in the same time frame. The results showed that pups from Group B, exhibited behavioural deficits in most tests, a significant reduction in body weight gain and absolute brain weight; in addition immunohistochemistry showed reactive astrogliosis induced by vanadium exposure. All these findings were however attenuated in pups whose dam was exposed to vanadium and vitamin E depicting the significant protective effects of this antioxidant against vanadium. This study is novel in that both vanadium and vitamin E were introduced through the lactation route. We conclude that though caution remains essential in the posology of vitamin E, the management of lactating mothers who have been exposed to vanadium occupationally, environmentally or therapeutically with supplementation of this antioxidant may be beneficial at least in the short term to both mother and offspring.
AuthorsJ O Olopade, I O Fatola, F E Olopade
JournalNigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria (Niger J Physiol Sci) Vol. 26 Issue 1 Pg. 55-60 (Nov 23 2011) ISSN: 0794-859X [Print] Nigeria
PMID22314988 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers
  • Glial Fibrillary Acidic Protein
  • Neuroprotective Agents
  • Vitamin E
  • Vanadates
Topics
  • Animals
  • Astrocytes (drug effects, metabolism, pathology)
  • Behavior, Animal (drug effects)
  • Biomarkers (metabolism)
  • Body Weight (drug effects)
  • Brain (drug effects, metabolism, pathology, physiopathology)
  • Female
  • Glial Fibrillary Acidic Protein (metabolism)
  • Immunohistochemistry
  • Injections, Intraperitoneal
  • Lactation
  • Maternal Exposure (adverse effects)
  • Milk (metabolism)
  • Motor Activity (drug effects)
  • Neuroprotective Agents (pharmacology)
  • Neurotoxicity Syndromes (etiology, metabolism, pathology, physiopathology, prevention & control, psychology)
  • Rats
  • Time Factors
  • Vanadates (administration & dosage, metabolism, toxicity)
  • Vitamin E (pharmacology)

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