Is apparent diffusion coefficient reliable and accurate for monitoring effects of antiangiogenic treatment in a longitudinal study?

Abstract

PURPOSE:

To evaluate the reliability and accuracy of the apparent diffusion coefficient (ADC) for monitoring antiangiogenic treatment in a longitudinal study.

MATERIALS AND METHODS:

Tumor volume and ADC were monitored by T2-weighted magnetic resonance imaging (MRI) and diffusion-weighted MRI, respectively, in 18 mice with angiogenesis-dependent tumors (U118MG) before (day 0) and after 2, 7, 14, and 21 days of administration of the antiangiogenic agent sunitinib maleate (n = 12) or vehicle (n = 6). Percent changes in tumor volume and ADC were calculated and correlations between tumor volume and ADC were evaluated.

RESULTS:

Tumor volume and ADC showed a negative correlation at 69 of the 72 (96%) follow-up measurements. In the 13 mice with tumor regrowth, ADC started to decrease before (27%) or at the same time (73%) as tumor regrowth. Pretreatment ADC and percent change in ADC change on days 0-2 were similar in mice with positive and negative responses to treatment (0.851 vs. 0.999, 24% vs. 16%). Percent change of ADC showed significant negative correlation with percent change in tumor volume in both the control (r = -0.69) and treated (r = -0.65) groups.

CONCLUSION:

Percent change in ADC is a reliable and accurate marker for monitoring the effects of antiangiogenic treatment, whereas pretreatment ADC and early changes in ADC (ie, days 0-2) are limited in predicting treatment outcome.

• Authors: Ji-Yeon Suh, Gyunggoo Cho, Youngkyu Song, Chang Kyung Lee, Jong Soon Kang, Moo Rim Kang, Sung Bin Park, Young Ro Kim, Jeong Kon Kim
• Journal: Journal of magnetic resonance imaging : JMRI (J Magn Reson Imaging) Vol. 35 Issue 6 Pg. 1430-6 (Jun 2012) ISSN: 1522-2586 [Electronic] United States
• PMID: 22314928 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Wiley Periodicals, Inc.

Chemical References

• Angiogenesis Inhibitors
• Antineoplastic Agents
• Indoles
• Pyrroles
• Sunitinib

Topics

• Angiogenesis Inhibitors (therapeutic use)
• Animals
• Antineoplastic Agents (therapeutic use)
• Diffusion Magnetic Resonance Imaging (methods)
• Female
• Glioblastoma (drug therapy, pathology)
• Image Enhancement (methods)
• Image Interpretation, Computer-Assisted (methods)
• Indoles (therapeutic use)
• Longitudinal Studies
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Neovascularization, Pathologic (drug therapy, pathology)
• Pyrroles (therapeutic use)
• Reproducibility of Results
• Sensitivity and Specificity
• Sunitinib
• Treatment Outcome