Abstract | AIM: To assess efficacy of two-stage treatment of severe genital herpes (GH) with regular recurrences: combined use of antivirus medicines with interferon preparations and its inductors followed by antirecurrence vaccine therapy. MATERIAL AND METHODS: Two-stage treatment was given to 100 patients suffering from GH with severe regular recurrences. One-stage treatment included famvir in combination with interferon ( viferon) or interferon inductors ( amixin, cycloferon) and antioxidants. Stage two treatment consisted of vaccine therapy of patients who failed prophylactic standard vaccination by allergometric technique. RESULTS: The first stage treatment prolonged recurrence-free period 2-3-fold in more than 85% patients, improved quality of life. Stage-two treatment resulted in long-term clinicoimmunological remission which is necessary for conduction of anti-recurrence vaccine treatment. CONCLUSION: Changes in therapeutic-preventive policy in patients with recurrent GH with regular recurrence (2 stage of treatment) prolong recurrence-free intervals, improve quality of life and social adaptation of patients.
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Authors | V A Isakov, D K Ermolenko, D V Isakov |
Journal | Terapevticheskii arkhiv
(Ter Arkh)
Vol. 83
Issue 11
Pg. 44-7
( 2011)
ISSN: 0040-3660 [Print] Russia (Federation) |
PMID | 22312884
(Publication Type: Journal Article)
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Chemical References |
- Acridines
- Antioxidants
- Antiviral Agents
- Herpes Simplex Virus Vaccines
- Interferon Inducers
- Interferon alpha-2
- Interferon-alpha
- Recombinant Proteins
- Tilorone
- 10-carboxymethyl-9-acridanone
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Topics |
- Acridines
(therapeutic use)
- Antioxidants
(therapeutic use)
- Antiviral Agents
(therapeutic use)
- Herpes Genitalis
(drug therapy, prevention & control)
- Herpes Simplex Virus Vaccines
(administration & dosage)
- Humans
- Interferon Inducers
(therapeutic use)
- Interferon alpha-2
- Interferon-alpha
(therapeutic use)
- Quality of Life
- Recombinant Proteins
(therapeutic use)
- Remission Induction
(methods)
- Secondary Prevention
- Severity of Illness Index
- Tilorone
(therapeutic use)
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