Abstract | PURPOSE: METHODS: RESULTS: We found that the numbers of several molecules were changed in the aqueous humor of patients with AMD compared to the control group. Among them, angiopoietin-2 was reduced by 20% and TCCR/WSX-1 was increased twofold. Moreover, exogenous TCCR protein induced tube formation and phosphorylation of extracellular signal-regulated kinase in human umbilical vein endothelial cells. CONCLUSIONS: Our study suggests that TCCR/WSX-1 is closely associated with angiogenesis and could serve as a novel therapeutic target in patients with AMD.
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Authors | Ho Jin Sung, Jung Il Han, Ji Won Lee, Ki Bang Uhm, Kyun Heo |
Journal | Molecular vision
(Mol Vis)
Vol. 18
Pg. 234-40
( 2012)
ISSN: 1090-0535 [Electronic] United States |
PMID | 22312192
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiogenesis Inhibitors
- Angiopoietin-2
- Biomarkers
- Eye Proteins
- IL27RA protein, human
- Receptors, Interleukin
- Vascular Endothelial Growth Factor A
- Extracellular Signal-Regulated MAP Kinases
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Topics |
- Aged
- Aged, 80 and over
- Angiogenesis Inhibitors
(pharmacology)
- Angiopoietin-2
(genetics, metabolism)
- Aqueous Humor
(metabolism)
- Biomarkers
(metabolism)
- Blotting, Western
- Cells, Cultured
- Enzyme-Linked Immunosorbent Assay
- Extracellular Signal-Regulated MAP Kinases
(genetics, metabolism)
- Eye
(blood supply)
- Eye Proteins
(genetics, metabolism)
- Female
- Gene Expression
- Human Umbilical Vein Endothelial Cells
(cytology, metabolism)
- Humans
- Macular Degeneration
(genetics, metabolism, pathology)
- Male
- Middle Aged
- Neovascularization, Pathologic
(genetics, metabolism)
- Protein Array Analysis
- Receptors, Interleukin
(genetics, metabolism)
- Vascular Endothelial Growth Factor A
(antagonists & inhibitors, metabolism)
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