Allogeneic transplantation of umbilical cord-derived mesenchymal stem cells for diffuse alveolar hemorrhage in systemic lupus erythematosus.

Abstract

Umbilical cord-derived mesenchymal stem cell transplantation (UC-MSCT) has been proved to be effective in the treatment of systemic lupus erythematosus (SLE), based on animal experiments and clinical trials. Diffuse alveolar hemorrhage (DAH) is a rare complication of SLE with a high mortality usually over 50%. This study aimed to assess the efficacy of UC-MSCT in the treatment of SLE-associated DAH. Four SLE patients complicated with DAH, who underwent UC-MSCT, were included. Clinical changes before and after transplantation were assessed by measurements of hemoglobin, platelet level, oxygen saturation, and serological factors. High-resolution CT (HRCT) scans of the chest were performed to evaluate pulmonary manifestation. All the four patients showed dramatic improvements of their clinical manifestations. Hemoglobin was elevated after UC-MSCT and was sustained at a normal level 6 months after UC-MSCT in the four patients. Platelet level was upregulated in two patients who had thrombocytopenia at baseline. Oxygen saturation appeared to be normal at 1 month after UC-MSCT, and this result was confirmed by the HRCT scan of the chest. Serum albumin elevated to 3.5 g/dl 6 months after transplantation. Our findings suggest that UC-MSCT results in amelioration of oxygen saturation as well as hematological and serologic changes, which revealed that UC-MSCT could be applied as a salvage strategy for DAH patients.

• Authors: Dongyan Shi, Dandan Wang, Xia Li, Huayong Zhang, Nan Che, Zhimin Lu, Lingyun Sun
• Journal: Clinical rheumatology (Clin Rheumatol) Vol. 31 Issue 5 Pg. 841-6 (May 2012) ISSN: 1434-9949 [Electronic] Germany
• PMID: 22302582 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Glucocorticoids
• Immunoglobulins

Topics

• Adult
• Anti-Bacterial Agents (therapeutic use)
• Combined Modality Therapy
• Cord Blood Stem Cell Transplantation
• Female
• Glucocorticoids (therapeutic use)
• Hemorrhage (complications, pathology, therapy)
• Humans
• Immunoglobulins (therapeutic use)
• Lung Diseases (complications, pathology, therapy)
• Lupus Erythematosus, Systemic (complications, pathology, therapy)
• Mesenchymal Stem Cell Transplantation (methods)
• Middle Aged
• Pulmonary Alveoli (pathology)
• Retrospective Studies
• Transplantation, Homologous
• Treatment Outcome
• Umbilical Cord (cytology)
• Young Adult