Chromoendoscopy with red phenol in the diagnosis of Helicobacter pylori infection.

Abstract

An analytic study to validate a diagnostic test was carried out at the Institute of Gastroenterology in Havana, Cuba in adult patients of both sexes in whom chromoendoscopy was carried out with red phenol at 0.1% over the gastric mucosa for the detection of Helicobacter pylori infection between November 2008 and December 2010. The staining with red phenol at 0.1% is included in the invasive tests for the diagnosis of Helicobacter pylori infection and of the reactive techniques. The sensibility of red phenol dye in the diagnosis of Helicobacter pylori infection in the patients studied was of 72.6% with a confidence interval (C.I.) of 95% (64.9 to 79.2%) and a specificity of 75.5% C.I. 95% (61.9 to 85.4%). The positive predictive value was of 89.8% C.I. 95% (83.1 to 94.1%) and the negative predictive value of 48.1% C.I. 95% (37.3 to 59.0%). The proportion of false positives was of 24.5% C.I. 95% (14.6 to 38.1%)and the proportion of false negatives was of 27.4% C.I. 95% (20.8 to 35.1%). The diagnostic accuracy of the dye on the patients studied was 73.3% C.I. 95% (66.7 to 79.0%). The diagnostic odds ratio was 8.17 C.I. 95% (3.88 to 17.23), the J Youden ratio of 0.5 and the Kappa coefficient of 0.40 C.I. 95% (0.27 to 0.54). The staining dye with red phenol at 0.1% resulted in a useful method in the diagnosis of Helicobacter pylori infection in the gastric mucosa, it can be applied in our environment and has multiple advantages (topographic localization, avoids contamination and fast and immediate reading).

• Authors: Héctor Rubén Hernández-Garcés, Víctor V Castellanos-González, Licet González-Fabián, Mirtha Infante-Velázquez, Kevin Peña, Yudit Andrain-Sierra
• Journal: Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva (Rev Esp Enferm Dig) Vol. 104 Issue 1 Pg. 4-9 (Feb 2012) ISSN: 1130-0108 [Print] Spain
• PMID: 22300110 (Publication Type: Journal Article)

Chemical References

• Coloring Agents
• Urease
• Phenolsulfonphthalein

Topics

• Adolescent
• Adult
• Age Factors
• Aged
• Coloring Agents
• Cuba
• Databases, Factual
• Endoscopy, Gastrointestinal
• Female
• Gastric Mucosa (pathology)
• Helicobacter Infections (diagnosis, pathology)
• Helicobacter pylori
• Humans
• Male
• Middle Aged
• Odds Ratio
• Phenolsulfonphthalein
• Predictive Value of Tests
• Sex Factors
• Urease (urine)
• Young Adult