Dynamic FDG PET for assessing early effects of cerebral hypoxia and resuscitation in new-born pigs.

Abstract

PURPOSE:

Changes in cerebral glucose metabolism may be an early prognostic indicator of perinatal hypoxic-ischaemic injury. In this study dynamic ¹⁸F-FDG PET was used to evaluate cerebral glucose metabolism in piglets after global perinatal hypoxia and the impact of the resuscitation strategy using room air or hyperoxia.

METHODS:

New-born piglets (n = 16) underwent 60 min of global hypoxia followed by 30 min of resuscitation with a fraction of inspired oxygen (FiO₂) of 0.21 or 1.0. Dynamic FDG PET, using a microPET system, was performed at baseline and repeated at the end of resuscitation under stabilized haemodynamic conditions. MRI at 3 T was performed for anatomic correlation. Global and regional cerebral metabolic rates of glucose (CMRgl) were assessed by Patlak analysis for the two time-points and resuscitation groups.

RESULTS:

Global hypoxia was found to cause an immediate decrease in cerebral glucose metabolism from a baseline level (mean ± SD) of 21.2 ± 7.9 to 12.6 ± 4.7 μmol/min/ 100 g (p <0.01). The basal ganglia, cerebellum and cortex showed the greatest decrease in CMRgl but no significant differences in global or regional CMRgl between the resuscitation groups were found.

CONCLUSION:

Dynamic FDG PET detected decreased cerebral glucose metabolism early after perinatal hypoxia in piglets. The decrease in CMRgl may indicate early changes of mild cerebral hypoxia-ischaemia. No significant effect of hyperoxic resuscitation on the degree of hypometabolism was found in this early phase after hypoxia. Cerebral FDG PET can provide new insights into mechanisms of perinatal hypoxic- ischaemic injury where early detection plays an important role in instituting therapy.

• Authors: Charlotte de Lange, Eirik Malinen, Hong Qu, Kjersti Johnsrud, Arne Skretting, Ola Didrik Saugstad, Berit H Munkeby
• Journal: European journal of nuclear medicine and molecular imaging (Eur J Nucl Med Mol Imaging) Vol. 39 Issue 5 Pg. 792-9 (May 2012) ISSN: 1619-7089 [Electronic] Germany
• PMID: 22297457 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fluorodeoxyglucose F18
• Glucose
• Oxygen

Topics

• Air
• Animals
• Animals, Newborn
• Brain (diagnostic imaging, metabolism)
• Fluorodeoxyglucose F18
• Glucose (metabolism)
• Humans
• Hypoxia, Brain (diagnostic imaging, drug therapy, metabolism)
• Male
• Oxygen (therapeutic use)
• Positron-Emission Tomography
• Swine
• Time Factors