Clinical significance of CADM1/TSLC1/IgSF4 expression in adult T-cell leukemia/lymphoma.

Abstract

Cell adhesion molecule 1 (CADM1/TSLC1) was recently identified as a novel cell surface marker for adult T-cell leukemia/lymphoma (ATLL). In this study, we developed various antibodies as diagnostic tools to identify CADM1-positive ATLL leukemia cells. In flow cytometric analysis, the percentages of CD4(+)CADM1(+) double-positive cells correlated well with both the percentages of CD4(+)CD25(+) cells and with abnormal lymphocytes in the peripheral blood of patients with various types of ATLL. Moreover, the degree of CD4(+)CADM1(+) cells over 1% significantly correlated with the copy number of the human T-lymphotropic virus type 1 (HTLV-1) provirus in the peripheral blood of HTLV-1 carriers and ATLL patients. We also identified a soluble form of CADM1 in the peripheral blood of ATLL patients, and the expression levels of this form were correlated with the levels of soluble interleukin 2 receptor alpha. Moreover, lymphomas derived from ATLL were strongly and specifically stained with a CADM1 antibody. Thus, detection of CD4(+)CADM1(+) cells in the peripheral blood, measurement of serum levels of soluble CADM1 and immunohistochemical detection of CADM1 in lymphomas would be a useful set of markers for disease progression in ATLL and may aid in both the early diagnosis and measurement of treatment efficacy for ATLL.

• Authors: S Nakahata, Y Saito, K Marutsuka, T Hidaka, K Maeda, K Hatakeyama, T Shiraga, A Goto, N Takamatsu, Y Asada, A Utsunomiya, A Okayama, Y Kubuki, K Shimoda, Y Ukai, G Kurosawa, K Morishita
• Journal: Leukemia (Leukemia) Vol. 26 Issue 6 Pg. 1238-46 (Jun 2012) ISSN: 1476-5551 [Electronic] England
• PMID: 22289924 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CADM1 protein, human
• Cell Adhesion Molecule-1
• Cell Adhesion Molecules
• DNA, Viral
• Immunoglobulins
• Tumor Suppressor Proteins

Topics

• Adult
• Case-Control Studies
• Cell Adhesion Molecule-1
• Cell Adhesion Molecules (immunology, metabolism)
• DNA, Viral (genetics)
• Disease Progression
• Flow Cytometry
• HTLV-I Infections (diagnosis, genetics, virology)
• Human T-lymphotropic virus 1 (genetics)
• Humans
• Immunoenzyme Techniques
• Immunoglobulins (immunology, metabolism)
• Leukemia-Lymphoma, Adult T-Cell (diagnosis, metabolism, virology)
• Lymphocytes (cytology, metabolism)
• Proviruses (genetics)
• Real-Time Polymerase Chain Reaction
• Tumor Suppressor Proteins (metabolism)
• Viral Load