Skin toxicity from external beam radiation therapy in breast cancer patients: protective effects of Resveratrol, Lycopene, Vitamin C and anthocianin (Ixor®).

Abstract

INTRODUCTION:

This is an observational study and the aim is to evaluate the effect of dietary supplements based on Resveratrol, Lycopene, Vitamin C and Anthocyanins (Ixor®) in reducing skin toxicity due to external beam radiotherapy in patients affected by breast cancer.

MATERIALS AND METHODS:

71 patients were enrolled and they were divided in two different groups: a control group (CG) of 41 patients treated with prophylactic topical therapy based on hyaluronic acid and topical steroid therapy in case of occurrence of radiodermatitis, and a Ixor-Group (IG) of 30 patients treated also with an oral therapy based on Resveratrol, Lycopene, Vitamin C and Anthocyanin (Ixor®) at a dose of 2 tablets/day, starting from 10 days before the radiation treatment until 10 days after the end of treatment. Skin toxicity has been related to PTV, to breast volume that received a radiation dose equal or lower than 107%, included between 107% and 110%, or greater than 110% of the prescribed dose. Moreover it's been studied the relationship between skin toxicity and the chemotherapy schedule used before treatment. We calculated in both groups the percentage of patients who had a skin toxicity of grade 2 or 3 (according to RTOG scale). Absolute risk reduction (ARR), relative risk (RR) and odds ratio (OR) have been calculated for each relationship.

RESULTS:

Control Group (CG) patients with a PTV > 500 ml presented skin toxicity G2 + G3 in 30% of cases, versus 25% of Ixor-Group (IG) [OR 0.77]. In patients with a PTV < 500 ml G2 + G3 toxicity was 0% in the IG compared to 18% in CG (OR 0.23). When Dmax was less than or equal to 107% of the prescribed dose skin toxicity was G2 + G3 in 12.5% in CG, versus 0% in IG (OR 0.73), instead when Dmax was included between 107 and 110% of the prescribed dose, G2 + G3 skin toxicity was 35% in CG and 21% in IG (OR 0.50). In patients undergoing chemotherapy with anthracyclines and taxanes, G2 + G3 toxicity was 27% in CG, against 20% in IG (OR 0.68).

CONCLUSIONS:

The protective effect of Resveratrol, Lycopene, Vitamin C and Anthocyanin (Ixor®) is more detected in patients with PTV < 500 ml, when Dmax reaches values lower or equal to 107%, but not exceeding 110% of the prescribed dose, and in patients undergoing adjuvant chemotherapy with anthracyclines and taxanes.

• Authors: Rossella Di Franco, MariaGrazia Calvanese, Paola Murino, Roberto Manzo, Cesare Guida, Davide Di Gennaro, Caterina Anania, Vincenzo Ravo
• Journal: Radiation oncology (London, England) (Radiat Oncol) Vol. 7 Pg. 12 (Jan 30 2012) ISSN: 1748-717X [Electronic] England
• PMID: 22289566 (Publication Type: Journal Article)

Chemical References

• Anthocyanins
• Antioxidants
• Radiation-Protective Agents
• Stilbenes
• Vitamins
• Carotenoids
• Ascorbic Acid
• Resveratrol
• Lycopene

Topics

• Adult
• Aged
• Aged, 80 and over
• Anthocyanins (therapeutic use)
• Antioxidants (therapeutic use)
• Ascorbic Acid (therapeutic use)
• Breast Neoplasms (complications, radiotherapy)
• Carotenoids (therapeutic use)
• Female
• Humans
• Lycopene
• Middle Aged
• Prognosis
• Radiation-Protective Agents (therapeutic use)
• Radiodermatitis (etiology, prevention & control)
• Radiotherapy, Conformal (adverse effects)
• Resveratrol
• Stilbenes (therapeutic use)
• Vitamins (therapeutic use)