Abstract | BACKGROUND: AIMS: METHODS:
Colitis was induced by intrarectal instillation of trinitrobenzene sulphonic acid (TNBS) (15 mg⁄mL) while losartan was administered orally daily by gavage (7 mg⁄kg⁄day) for 21 days. Three groups of rats were evaluated: control (n=10); TNBS treated (n=10); and TNBS + losartan treated (n=10). Inflammation and fibrosis of the colon were evaluated by macro- and microscopic score analysis. Colonic TGF-b1 levels was measured using ELISA. RESULTS: Twenty-one days after induction, losartan significantly improved the macro- and microscopic scores of fibrosis in the colonic wall and reduced TGF-b1 concentration. CONCLUSIONS:
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Authors | Dov Wengrower, Giuliana Zanninelli, Giovanni Latella, Stefano Necozione, Issa Metanes, Eran Israeli, Joseph Lysy, Mark Pines, Orit Papo, Eran Goldin |
Journal | Canadian journal of gastroenterology = Journal canadien de gastroenterologie
(Can J Gastroenterol)
Vol. 26
Issue 1
Pg. 33-9
(Jan 2012)
ISSN: 0835-7900 [Print] Canada |
PMID | 22288068
(Publication Type: Journal Article)
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Chemical References |
- Angiotensin II Type 1 Receptor Blockers
- Transforming Growth Factor beta1
- Trinitrobenzenesulfonic Acid
- Losartan
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Topics |
- Angiotensin II Type 1 Receptor Blockers
(administration & dosage, pharmacology, therapeutic use)
- Animals
- Colitis
(chemically induced, drug therapy, pathology, physiopathology)
- Disease Models, Animal
- Disease Progression
- Down-Regulation
(drug effects)
- Fibrosis
- Intestinal Mucosa
(chemistry, pathology)
- Losartan
(administration & dosage, pharmacology, therapeutic use)
- Male
- Rats
- Transforming Growth Factor beta1
(metabolism, physiology)
- Trinitrobenzenesulfonic Acid
(adverse effects)
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