Histone modification defects in developmental disorders and cancer.

Abstract

Clinically, Weaver syndrome is closely related to Sotos syndrome, which is frequently caused by mutations in NSD1. This gene also encodes a histone methyltransferase, in this case with activity against histone H3 lysine 36. NSD1 is mutated in carcinoma of the upper aerodigestive tract (www.sanger.ac.uk/genetics/CGP/cosmic/) and also fuses to NUP98 in acute myeloid leukemia. Looking more widely, whole exome screens in lymphoma, multiple myeloma, renal carcinoma and other malignancies have identified genes encoding diverse histone modifiers as targets of somatic mutation. Strikingly, several of these (e.g. MLL2, EP300, CREBBP, ASXL1) are also mutated in human developmental disorders thus pointing towards a remarkable and unexpected convergence between somatic and germline genetics.

• Authors: Nicholas C P Cross
• Journal: Oncotarget (Oncotarget) Vol. 3 Issue 1 Pg. 3-4 (Jan 2012) ISSN: 1949-2553 [Electronic] United States
• PMID: 22287508 (Publication Type: Editorial, Comment)

Chemical References

• DNA-Binding Proteins
• Transcription Factors

Topics

• Abnormalities, Multiple (genetics)
• Congenital Hypothyroidism (genetics)
• Craniofacial Abnormalities (genetics)
• DNA-Binding Proteins (genetics)
• Female
• Germ-Line Mutation
• Hand Deformities, Congenital (genetics)
• Humans
• Male
• Transcription Factors (genetics)