Long-term effects of systemic cancer treatment on DNA oxidative damage: the potential for targeted therapies.

Abstract

The main pathological consequence of free radical exposure is DNA damage, which is known to induce cell transformation and to facilitate important mutations in cancer progression. It is a matter of intense discussion whether the drug-induced production of free radicals limits the therapeutic efficacy of chemotherapeutics and enhances their toxicity or whether they may be enhanced to provoke cancer cell apoptosis. This paper reviews essential molecular processes to better understand the controversial role of free radicals in cancer development and progression, and discusses some novel therapeutic strategies based on oxidative stress induction and prevention.

• Authors: Laura Vera-Ramirez, McArmen Ramirez-Tortosa, Patricia Perez-Lopez, Sergio Granados-Principal, Maurizio Battino, José L Quiles
• Journal: Cancer letters (Cancer Lett) Vol. 327 Issue 1-2 Pg. 134-41 (Dec 31 2012) ISSN: 1872-7980 [Electronic] Ireland
• PMID: 22274413 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Antioxidants
• Reactive Oxygen Species

Topics

• Animals
• Antineoplastic Agents (administration & dosage, adverse effects, therapeutic use)
• Antioxidants (administration & dosage, adverse effects, therapeutic use)
• Apoptosis (drug effects)
• DNA Damage (drug effects)
• Gene Expression Regulation, Neoplastic (drug effects)
• Humans
• Molecular Targeted Therapy
• Neoplasms (drug therapy, genetics, metabolism, pathology)
• Oxidative Stress (drug effects)
• Reactive Oxygen Species (metabolism)
• Signal Transduction (drug effects)
• Time Factors