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Ruthenium-106 brachytherapy and intravitreal bevacizumab for retinal capillary hemangioma.

Abstract
The purpose of this study is to report a case of retinal capillary hemangioma treated with ruthenium-106 brachytherapy combined with intravitreal bevacizumab. A 58-year-old woman presented with blurred vision in her left eye for 15 days. Best-corrected visual acuity (BCVA) was counting fingers at 3 m in her left eye. Examination showed a peripheral endophytic retinal capillary hemangioma, with associated macular edema and diffuse hard exudates in a macular star pattern. B-scan ultrasonography revealed a solid, highly reflective retinal tumor measuring 7.1 × 7.5 mm in basal dimension and 3.5 mm in thickness. The hemangioma and macular edema were treated with ruthenium-106 brachytherapy (500 Gy) followed 1 month later with an intravitreal injection of 1.25 mg (0.05 ml) bevacizumab. After 10 months of follow-up, examination demonstrated involution of the hemangioma, resolution of the macular edema, less hard exudates, and improvement of BCVA to 20/25. Ruthenium-106 brachytherapy combined with intravitreal bevacizumab was associated with significant involution of the choroidal hemangioma with resolution of the macular edema and improvement in visual acuity.
AuthorsVincenzo Russo, Andrea Stella, Antonio Barone, Ingrid U Scott, Nicola Delle Noci
JournalInternational ophthalmology (Int Ophthalmol) Vol. 32 Issue 1 Pg. 71-5 (Feb 2012) ISSN: 1573-2630 [Electronic] Netherlands
PMID22271068 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Angiogenesis Inhibitors
  • Antibodies, Monoclonal, Humanized
  • Ruthenium Radioisotopes
  • Vascular Endothelial Growth Factor A
  • Bevacizumab
Topics
  • Angiogenesis Inhibitors (administration & dosage)
  • Antibodies, Monoclonal, Humanized (administration & dosage)
  • Bevacizumab
  • Brachytherapy (methods)
  • Diagnosis, Differential
  • Female
  • Follow-Up Studies
  • Hemangioma, Capillary (diagnosis, drug therapy, radiotherapy)
  • Humans
  • Intravitreal Injections
  • Magnetic Resonance Imaging
  • Middle Aged
  • Retinal Neoplasms (diagnosis, drug therapy, radiotherapy)
  • Ruthenium Radioisotopes (therapeutic use)
  • Tomography, Optical Coherence
  • Vascular Endothelial Growth Factor A (antagonists & inhibitors)
  • Visual Acuity

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