Pregnancy in a woman with congenital generalized lipodystrophy: leptin's vital role in reproduction.

Abstract

BACKGROUND:

Congenital generalized lipodystrophy is a rare disorder characterized by scant adipose tissue, profound leptin deficiency, and severe insulin resistance, resulting in multiple metabolic derangements, including hyperandrogenism, anovulation, and impaired fecundity.

CASE:

A young woman with congenital generalized lipodystrophy receiving leptin therapy experienced menarche, conceived spontaneously, and delivered a liveborn male neonate.

CONCLUSION:

Adipose tissue is important to normal female reproductive function. Leptin in particular appears to play a key role in adipose-mediated regulation of fertility.

• Authors: Marcy Maguire, Andrea Lungu, Phillip Gorden, Elaine Cochran, Pamela Stratton
• Journal: Obstetrics and gynecology (Obstet Gynecol) Vol. 119 Issue 2 Pt 2 Pg. 452-455 (Feb 2012) ISSN: 1873-233X [Electronic] United States
• PMID: 22270436 (Publication Type: Case Reports, Journal Article)

Chemical References

• Blood Glucose
• Glycated Hemoglobin A
• Insulin
• Leptin

Topics

• Blood Glucose (metabolism)
• Female
• Glycated Hemoglobin (metabolism)
• Humans
• Insulin (therapeutic use)
• Leptin (therapeutic use)
• Lipodystrophy (blood, congenital, drug therapy)
• Live Birth
• Pregnancy
• Pregnancy Complications (blood)