[Pompholyx-like reactions occurring early in treatment of severe atopic dermatitis in children and adolescence].

Abstract

BACKGROUND:

Pompholyx-like reactions may develop for aggressive atopic dermatitis treatments in the incipient phase despite of improvement of other skin symptoms.

METHODS:

Eighty-nine patients admitted to National Center for Child Health and Development for treatment of atopic dermatitis between April 2007 and March 2009 were recruited.

RESULTS:

Pompholyx-like reactions were seen in thirteen out of eighty-nine patients between 4 and 32 (mean 16.7±10.4) days following admission. The mean age of patients with these reactions was 6.2±6.1 years (range of 3 months to 23 years). At the time of admission, practical issues of scoring atopic dermatitis: the SCORAD was assessed. The values of SCORAD index with pompholyx were ranging from 16-91 (mean 50.8±17.9), and the index except under one-year old were significantly higher than unaffected patients. These patients were evaluated into their medical record, for evidence of Pompholyx-like lesions: a bilateral vesicular eruption confined to the skin of the palms, soles, or sides of the fingers. Topical corticosteroids are used to treat Pompholyx-like reactions, all them achieved remission between 4 and 50 days (mean 18.5±12.0). In general, pompholyx is more common in summer. However, it seems that there were no significant differences in the pompholyx-like reactions incidence between in summer and in winter.

CONCLUSION:

The factor for the occurrence of pompholyx-like lesions remains unexplained. Although the original symptoms of eczema were improved, pompholyx-like eczema breakout, therefore, patients often feel uneasy. We should be aware of this clinical condition.

• Authors: Kenta Horimukai, Yuki Tsumura, Kiwako Yamamoto, Tetsuo Shoda, Masaki Futamura, Ichiro Nomura, Masami Narita, Yukihiro Ohya
• Journal: Arerugi = [Allergy] (Arerugi) Vol. 60 Issue 11 Pg. 1543-9 (Nov 2011) ISSN: 0021-4884 [Print] Japan
• PMID: 22270129 (Publication Type: English Abstract, Journal Article)

Topics

• Adolescent
• Child
• Child, Preschool
• Dermatitis, Atopic (complications, drug therapy)
• Eczema, Dyshidrotic (etiology, pathology)
• Female
• Humans
• Infant
• Male
• Young Adult