Hybrid liposomes inhibit growth and invasion of human osteosarcoma cells leading to apoptosis.

Abstract

Marked inhibitory effects of hybrid liposomes (HL-n; n=21, 23, 25) composed of 90 mol% l-α-dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(n) dodecyl ethers on the growth of two human osteosarcoma cell lines (MG-63 and U-2 OS) were obtained. Furthermore, fluorescence microscopic and flow cytometric analyses revealed the induction of apoptosis by HL-n in both cells. It is noteworthy that HL-23 could inhibit the invasion and migration of U-2 OS cells on the basis of matrigel invasion assay and scratch wound assay, respectively.

• Authors: Hideki Kitajima, Yuji Komizu, Ryuichi Ueoka
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 22 Issue 4 Pg. 1784-7 (Feb 15 2012) ISSN: 1464-3405 [Electronic] England
• PMID: 22260774 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ltd. All rights reserved.

Chemical References

• Liposomes
• Polyethylene Glycols
• Dimyristoylphosphatidylcholine

Topics

• Apoptosis (drug effects)
• Cell Line, Tumor
• Cell Movement (drug effects)
• Dimyristoylphosphatidylcholine (chemistry, pharmacology)
• Flow Cytometry
• Humans
• Inhibitory Concentration 50
• Liposomes (chemistry, pharmacology)
• Molecular Structure
• Neoplasm Invasiveness
• Osteosarcoma (drug therapy)
• Polyethylene Glycols (chemistry, pharmacology)