PPARs play a pivotal role in regulating
lipid and
glucose homeostasis and are involved in diverse
biological activities in skin. Pomegranate flower (
PGF, an
antidiabetic therapy in Unani and Ayurvedic medicines) has been previously demonstrated to activate both
PPARalpha/gamma. Here, we found that treatment of mice with the diet containing
PGF powder over 55 weeks attenuated ageing-induced abnormal increases in the homeostasis model assessment of
insulin resistance,
glucose concentrations during oral
glucose tolerance test, and adipose
insulin resistance index. The diet tended to decrease the excessive peri-ovary fat mass. It, however, increased the thinned subcutaneous fat thickness. In addition, the diet restored decreases in skin water content, epidermis thickness, and
collagen density in corium. Thus, our results demonstrate that long-term treatment with the Unani and Ayurvedic
therapy ameliorates ageing-induced
insulin resistance, which is associated with reversal of ageing-induced fat redistribution. Further,
PGF attenuates ageing-mediated undesirable
skin abnormalities.