HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Hip fracture incidence is decreasing in the high incidence area of Oslo, Norway.

AbstractUNLABELLED:
This study reports a significant decrease in age-adjusted incidence rates of hip fracture for women in Oslo, Norway, even compared with data from 1978/1979. Use of bisphosphonate may explain up to one third of the decline in the incidence.
INTRODUCTION:
The aims of the present study were to report the current incidence of hip fractures in Oslo and to estimate the influence of bisphosphonates on the current incidence.
METHODS:
Using the electronic diagnosis registers and lists from the operating theaters of the hospitals of Oslo, all patients with ICD-10 codes S72.0 and S72.1 (hip fracture) in 2007 were identified. Medical records of all identified patients were reviewed to verify the diagnosis. Age- and gender-specific annual incidence rates were calculated using the population of Oslo on January 1, 2007 as the population at risk. Data on the use of bisphosphonates were obtained from official registers.
RESULTS:
A total number of 1,005 hip fractures, 712 (71%) in women, were included. The age-adjusted fracture rates per 10,000 for the age group >50 years were 82.0 for women and 39.1 for men in 2007, compared with 110.8 and 41.4 in 1996/1997, 116.5 and 42.9 in 1988/1989, and 97.5 and 34.5 in 1978/1979, respectively. It was estimated that the use of bisphosphonates may explain up to 13% of the decline in incidence in women aged 60-69 years and up to 34% in women aged 70-79 years.
CONCLUSIONS:
The incidence of hip fractures in women in Oslo has decreased significantly during the last decade and is now at a lower level than in 1978/1979. This reduction was not evident in men. The incidence of hip fractures in Oslo is, however, still the highest in the world.
AuthorsR O Støen, L Nordsletten, H E Meyer, J F Frihagen, J A Falch, C M Lofthus
JournalOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (Osteoporos Int) Vol. 23 Issue 10 Pg. 2527-34 (Oct 2012) ISSN: 1433-2965 [Electronic] England
PMID22246602 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
Chemical References
  • Bone Density Conservation Agents
  • Diphosphonates
Topics
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Bone Density Conservation Agents (therapeutic use)
  • Diphosphonates (therapeutic use)
  • Drug Utilization (statistics & numerical data)
  • Emigration and Immigration
  • Female
  • Hip Fractures (epidemiology, prevention & control)
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Norway (epidemiology)
  • Sex Distribution

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: