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Urinary incontinence in children: botulinum toxin is a safe and effective treatment option.

AbstractPURPOSE:
This study's aim was to assess the use of intravesical injection of botulinum neurotoxin type A (BoNT-A) as a treatment of overactive bladder (OAB) in children.
METHODS:
A 6-year retrospective study of children who received BoNT-A for OAB was performed. Treatment outcome was classified as complete success (CS), partial success (PS) or treatment failure (TF).
RESULTS:
Of the 57 patients who received BoNT-A treatment for OAB, 35 were males. CS occurred in 74.2% of males and 54.5% of females. PS was achieved in 20% of males and 18.2% of females. TF occurred in 2.9% of males and 22.7% of females. Anticholinergics had previously been used and had been effective in 58.6% and 83.3% of males and females. Significant side effects to medications were experienced in 12 (41.4%) males and 4 (22.2%) females. Of these, BoNT-A achieved CS in seven (53.3%) males and two (50%) females and PS in three (25%) males and one (25%) female. BoNT-A was successful in seven (58.3%) males and two (66.7%) females where anticholinergics were ineffective.
CONCLUSIONS:
BoNT-A has a role in a carefully selected subgroup of children with overactive bladder symptoms including those with medication side effects and treatment compliance issues. It may have a role in patients who do not respond to conventional therapy.
AuthorsDermot Thomas McDowell, Damien Noone, Farhan Tareen, Mary Waldron, Feargal Quinn
JournalPediatric surgery international (Pediatr Surg Int) Vol. 28 Issue 3 Pg. 315-20 (Mar 2012) ISSN: 1437-9813 [Electronic] Germany
PMID22246390 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Neuromuscular Agents
  • Botulinum Toxins, Type A
  • incobotulinumtoxinA
Topics
  • Administration, Intravesical
  • Adolescent
  • Botulinum Toxins, Type A (administration & dosage)
  • Child
  • Child, Preschool
  • Dose-Response Relationship, Drug
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Neuromuscular Agents (administration & dosage)
  • Retrospective Studies
  • Time Factors
  • Treatment Outcome
  • Urinary Bladder, Overactive (drug therapy, physiopathology)
  • Urinary Incontinence (drug therapy)
  • Urodynamics (drug effects)

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