Abstract | PURPOSE: METHODS: A 6-year retrospective study of children who received BoNT-A for OAB was performed. Treatment outcome was classified as complete success (CS), partial success (PS) or treatment failure (TF). RESULTS: Of the 57 patients who received BoNT-A treatment for OAB, 35 were males. CS occurred in 74.2% of males and 54.5% of females. PS was achieved in 20% of males and 18.2% of females. TF occurred in 2.9% of males and 22.7% of females. Anticholinergics had previously been used and had been effective in 58.6% and 83.3% of males and females. Significant side effects to medications were experienced in 12 (41.4%) males and 4 (22.2%) females. Of these, BoNT-A achieved CS in seven (53.3%) males and two (50%) females and PS in three (25%) males and one (25%) female. BoNT-A was successful in seven (58.3%) males and two (66.7%) females where anticholinergics were ineffective. CONCLUSIONS:
BoNT-A has a role in a carefully selected subgroup of children with overactive bladder symptoms including those with medication side effects and treatment compliance issues. It may have a role in patients who do not respond to conventional therapy.
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Authors | Dermot Thomas McDowell, Damien Noone, Farhan Tareen, Mary Waldron, Feargal Quinn |
Journal | Pediatric surgery international
(Pediatr Surg Int)
Vol. 28
Issue 3
Pg. 315-20
(Mar 2012)
ISSN: 1437-9813 [Electronic] Germany |
PMID | 22246390
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Neuromuscular Agents
- Botulinum Toxins, Type A
- incobotulinumtoxinA
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Topics |
- Administration, Intravesical
- Adolescent
- Botulinum Toxins, Type A
(administration & dosage)
- Child
- Child, Preschool
- Dose-Response Relationship, Drug
- Female
- Follow-Up Studies
- Humans
- Male
- Neuromuscular Agents
(administration & dosage)
- Retrospective Studies
- Time Factors
- Treatment Outcome
- Urinary Bladder, Overactive
(drug therapy, physiopathology)
- Urinary Incontinence
(drug therapy)
- Urodynamics
(drug effects)
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