HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effects of vinblastine on microvascular anastomosis healing in diabetic rats.

AbstractOBJECTIVE:
Diabetes mellitus and chemotherapy use are well-known factors that can affect success after microvascular repair. Although many studies have investigated each factor individually, no study exists on their combined effect. The aim of our study was to investigate the effects of preoperative vinblastine, a vinca alkaloid, on the healing of microvascular anastomosis in diabetic and non-diabetic rats.
METHODS:
In this study, 144 Sprague Dawley rats were assigned randomly and equally into experimental or control groups. The experimental group consisted of 72 rats which were made diabetic by alloxan injections. Diabetes was confirmed by glycosuria (>2%) and elevated plasma glucose (>300 mg/100 ml) after three days of alloxan injections. The experimental group then received a single dose of intraperitoneal vinblastine. After applying the medication, the two main groups were divided into three subgroups. For each group, we performed end-to-end femoral artery anastomosis on Day 7, 14, and 21, respectively. We further divided each subgroup equally into three smaller groups to test patency and took biopsies at Day 7, 14 and 21, respectively. Histopathologic evaluation was carried out.
RESULTS:
The comparison of patency tests and pathologic examination indicated that there was no statistically significant difference between the two groups.
CONCLUSION:
The negative effects of diabetes and the administration of vinblastine did not significantly influence anastomosis healing.
AuthorsSemra Karşidağ, Soner Tatlidede, Uğur Tosun, Kemalettin Yildiz, Fevziye Kabukçuoğlu, Arzu Akçal
JournalActa orthopaedica et traumatologica turcica (Acta Orthop Traumatol Turc) Vol. 45 Issue 6 Pg. 446-52 ( 2011) ISSN: 2589-1294 [Electronic] Turkey
PMID22245822 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Blood Glucose
  • Vinblastine
Topics
  • Anastomosis, Surgical
  • Animals
  • Antineoplastic Agents, Phytogenic (pharmacology)
  • Blood Glucose (analysis)
  • Diabetes Mellitus, Experimental (blood, physiopathology)
  • Femoral Artery (surgery)
  • Male
  • Microsurgery
  • Rats
  • Rats, Sprague-Dawley
  • Vascular Patency
  • Vinblastine (pharmacology)
  • Wound Healing (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: