Abstract | BACKGROUND: Renal dysfunction is associated with increased mortality in patients with decompensated heart failure. However, interventions targeted to prevention in this setting have been disappointing. We investigated the effects of hypertonic saline solution (HSS) for prevention of renal dysfunction in decompensated heart failure. METHODS: RESULTS: Twenty-two patients were assigned to HSS and 12 to placebo. Primary end point occurred in two (10%) patients in HSS group and six (50%) in placebo group (relative risk 0.3; 95% CI 0.09-0.98; P=0.01). Relative to baseline, serum creatinine and cystatin C levels were lower in HSS as compared to placebo (P=0.004 and 0.03, respectively). NGAL level was not statistically different between groups, however the urinary expression of AQP2, UT-A1 and NHE3 was significantly higher in HSS than in placebo. CONCLUSIONS: HSS administration attenuated heart failure-induced kidney dysfunction as indicated by improvement in both glomerular and tubular defects, a finding with important clinical implications. HSS modulated the expression of tubular proteins involved in regulation of water and electrolyte homeostasis.
|
Authors | Victor S Issa, Lucia Andrade, Silvia M Ayub-Ferreira, Fernando Bacal, Ana C de Bragança, Guilherme V Guimarães, Fabiana G Marcondes-Braga, Fátima D Cruz, Paulo R Chizzola, Germano E Conceição-Souza, Irineu T Velasco, Edimar A Bocchi |
Journal | International journal of cardiology
(Int J Cardiol)
Vol. 167
Issue 1
Pg. 34-40
(Jul 15 2013)
ISSN: 1874-1754 [Electronic] Netherlands |
PMID | 22243938
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Saline Solution, Hypertonic
|
Topics |
- Adult
- Aged
- Double-Blind Method
- Female
- Fluid Therapy
(methods)
- Heart Failure
(epidemiology, physiopathology, therapy)
- Humans
- Kidney Diseases
(epidemiology, physiopathology, prevention & control)
- Male
- Middle Aged
- Saline Solution, Hypertonic
(administration & dosage)
|