Protective effects of Ginkgo biloba extract on ligature-induced periodontitis in rats.

Abstract

OBJECTIVE:

The aim of this study was to test the hypothesis that the systemic administration of extract of Ginkgo biloba (EGb) would prevent excessive tissue destruction in ligature-induced periodontitis in a rat model.

MATERIALS AND METHODS:

Thirty-two male Wistar albino rats were used in the current study. The rats were randomly divided into four groups of eight rats each: (1) non-ligated treatment (NL) group, (2) ligature-only (LO) group, (3) ligature plus GB28 (28 mg/kg, daily for 11 days) group and (4) ligature plus GB56 (56 mg/kg, daily for 11 days) group.

RESULTS:

Measurement of alveolar bone loss in the mandibular molar tooth revealed significantly lower bone loss values in the LO group compared to groups NL, GB28 and GB56 (p < 0.05).

CONCLUSION:

The present results are the first data which suggests that host response in periodontitis can be modified by EGb administration. EGb minimized progression of periodontal disease.

• Authors: Ufuk Sezer, Muhammet İsa Kara, Kamile Ercıyas, Hakan Ozdemir, Kemal Üstün, Hatice Ozer, Fahrettin Göze
• Journal: Acta odontologica Scandinavica (Acta Odontol Scand) Vol. 71 Issue 1 Pg. 38-44 (Jan 2013) ISSN: 1502-3850 [Electronic] England
• PMID: 22242550 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Plant Extracts

Topics

• Alveolar Bone Loss (etiology, prevention & control)
• Animals
• Antioxidants (therapeutic use)
• Ginkgo biloba
• Male
• Orthodontic Appliances (adverse effects)
• Periodontitis (etiology, prevention & control)
• Phytotherapy
• Plant Extracts (therapeutic use)
• Rats
• Rats, Wistar