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Induction of apoptosis in human breast adenocarcinoma cells MCF-7 by monapurpyridine A, a new azaphilone derivative from Monascus purpureus NTU 568.

Abstract
A new azaphilonidal derivative, monapurpyridine A (MPA), has recently been isolated from the fermented products of Monascus purpureus NTU 568. The structure of MPA was elucidated by nuclear magnetic resonance (1H-NMR, 13C-NMR, COSY, HMQC, and HMBC) and other spectroscopic analyses. Biological evaluation revealed that MPA could induce cell death in human breast adenocarcinoma cells MCF-7, and it has no significant toxicity to normal mammary epithelial cells M10. The MTT assay and flow cytometric analysis were employed to investigate cell viability and cell cycle influenced by MPA. Moreover, we used Western blot and caspase activity assay to demonstrate the activation of caspase-3, -8 and -9 resulted from MPA. All evidence supported that MPA was suitable for developing into a chemotherapeutic or chemopreventive agent against breast cancer.
AuthorsLi-Chuan Hsu, Ya-Wen Hsu, Yu-Han Liang, Chia-Ching Liaw, Yao-Haur Kuo, Tzu-Ming Pan
JournalMolecules (Basel, Switzerland) (Molecules) Vol. 17 Issue 1 Pg. 664-73 (Jan 11 2012) ISSN: 1420-3049 [Electronic] Switzerland
PMID22237681 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Culture Media
  • Pyridines
  • monapurpyridine A
  • Caspases
Topics
  • Adenocarcinoma
  • Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
  • Apoptosis (drug effects)
  • Breast Neoplasms
  • Caspases (metabolism)
  • Cell Line, Tumor
  • Cell Survival (drug effects)
  • Culture Media (chemistry)
  • Enzyme Activation
  • Female
  • Fermentation
  • Humans
  • Molecular Structure
  • Monascus (metabolism)
  • Oryza (chemistry)
  • Pyridines (chemistry, isolation & purification, pharmacology)

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