Abstract | BACKGROUND: OBJECTIVE: DESIGN: RESULTS: At 6 mo of diet intervention, the T allele of rs2287019 was associated with greater weight loss (β ± SE: -1.05 ± 0.56%; P = 0.06) and greater decreases in fasting glucose (β ± SE: -2.33 ± 0.86%; P = 0.006), fasting insulin (β ± SE: -8.76 ± 4.13%; P = 0.03), and HOMA-IR (β ± SE: -10.52 ± 4.39%; P = 0.01) in participants who were assigned to low-fat diets, whereas there was no significant genotype effect on changes in these traits in the group assigned to the high-fat diet (all P > 0.44; P-interaction = 0.08, 0.04, 0.10, and 0.07, respectively). After correction for multiple tests (significant P = 0.008), the genotype effect on changes in fasting glucose remained significant. Sensitivity analysis in white participants showed that the interactions were more evident on changes in insulin and HOMA-IR (P-interaction < 0.008). CONCLUSION: The T allele of GIPR rs2287019 is associated with greater improvement of glucose homeostasis in individuals who choose a low-fat, high- carbohydrate, and high-fiber diet. The POUNDS LOST trial was registered at clinicaltrials.gov as NCT00072995.
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Authors | Qibin Qi, George A Bray, Frank B Hu, Frank M Sacks, Lu Qi |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 95
Issue 2
Pg. 506-13
(Feb 2012)
ISSN: 1938-3207 [Electronic] United States |
PMID | 22237064
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Dietary Fats
- Insulin
- Receptors, Gastrointestinal Hormone
- gastric inhibitory polypeptide receptor
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Topics |
- Adult
- Alleles
- Blood Glucose
(metabolism)
- Diet, Fat-Restricted
- Diet, Reducing
- Dietary Fats
- Fasting
- Female
- Genotype
- Humans
- Insulin
(blood)
- Insulin Resistance
(genetics)
- Male
- Middle Aged
- Overweight
(blood, diet therapy, genetics)
- Polymorphism, Single Nucleotide
- Receptors, Gastrointestinal Hormone
(genetics)
- Weight Loss
(genetics)
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