Granulosa cell tumors of the ovary and inhibin B.

Abstract

We present the results of immunoenzyme detection of inhibin B in blood serum of patients with adult-type granulosa cell tumors of the ovary. Blood concentration of inhibin B at the end of menstrual cycle in patients with tumor relapse was significantly higher than in patients during remission and in virtually healthy women. The increase in inhibin B concentration preceded clinical manifestation of the disease relapse by 2-13 months, which demonstrates high diagnostic sensitivity of this marker and suggests that it can be recommended for the use in diagnostics and monitoring of granulosa cell tumors of the ovaries.

• Authors: N V Lyubimova, A M Beyshembaev, D N Kushlinskiy, K I Zordania, L V Adamyan
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 150 Issue 5 Pg. 635-8 (Mar 2011) ISSN: 1573-8221 [Electronic] United States
• PMID: 22235403 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• inhibin B
• Inhibins

Topics

• Adolescent
• Adult
• Aged
• Biomarkers, Tumor (blood)
• Female
• Granulosa Cell Tumor (blood, diagnosis)
• Humans
• Inhibins (blood)
• Menstrual Cycle (blood)
• Middle Aged
• Neoplasm Recurrence, Local
• Ovarian Follicle (metabolism)
• Ovarian Neoplasms (blood, diagnosis)
• Ovary (pathology)
• Young Adult