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Cyclodextrin-erythromycin complexes as a drug delivery device for orthopedic application.

AbstractBACKGROUND:
Erythromycin, a hydrophobic antibiotic used to treat infectious diseases, is now gaining attention because of its anti-inflammatory effects and ability to inhibit osteoclasts formation. The aim of this study was to explore a cyclodextrin-erythromycin (CD-EM) complex for sustained treatment of orthopedic inflammation.
METHODS AND RESULTS:
Erythromycin was reacted with β-cyclodextrin to form a nonhost-guest CD-EM complex using both kneading and stirring approaches. Physiochemical measurement data indicated that erythromycin and cyclodextrin formed a packing complex driven by intermolecular forces instead of a host-guest structure due to the limited space in the inner cavity of β-cyclodextrin. The CD-EM complex improved the stability of erythromycin in aqueous solution and had a longer duration of bactericidal activity than free erythromycin. Cytotoxicity and cell differentiation were evaluated in both murine MC3T3 preosteoblast cells and RAW 264.7 murine macrophage cells. The CD-EM complex was noncytotoxic and showed significant inhibition of osteoclast formation but had little effect on osteoblast viability and differentiation.
CONCLUSION:
These attributes are especially important for the delivery of an adequate amount of erythromycin to the site of periprosthetic inflammation and reducing local inflammation in a sustained manner.
AuthorsWei Song, Xiaowei Yu, Sunxi Wang, Ralph Blasier, David C Markel, Guangzhao Mao, Tong Shi, Weiping Ren
JournalInternational journal of nanomedicine (Int J Nanomedicine) Vol. 6 Pg. 3173-86 ( 2011) ISSN: 1178-2013 [Electronic] New Zealand
PMID22228990 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents
  • Cyclodextrins
  • Nanocapsules
  • Erythromycin
Topics
  • Anti-Inflammatory Agents (administration & dosage, chemistry)
  • Apoptosis (drug effects)
  • Cell Line
  • Cell Proliferation (drug effects)
  • Cyclodextrins (administration & dosage, chemistry)
  • Drug Therapy, Combination (methods)
  • Erythromycin (administration & dosage, chemistry)
  • Humans
  • Nanocapsules (administration & dosage, chemistry)
  • Osteoblasts (cytology, drug effects)
  • Osteoclasts (cytology, drug effects)

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