Abstract | BACKGROUND: METHODS AND RESULTS:
Erythromycin was reacted with β- cyclodextrin to form a nonhost-guest CD-EM complex using both kneading and stirring approaches. Physiochemical measurement data indicated that erythromycin and cyclodextrin formed a packing complex driven by intermolecular forces instead of a host-guest structure due to the limited space in the inner cavity of β- cyclodextrin. The CD-EM complex improved the stability of erythromycin in aqueous solution and had a longer duration of bactericidal activity than free erythromycin. Cytotoxicity and cell differentiation were evaluated in both murine MC3T3 preosteoblast cells and RAW 264.7 murine macrophage cells. The CD-EM complex was noncytotoxic and showed significant inhibition of osteoclast formation but had little effect on osteoblast viability and differentiation. CONCLUSION: These attributes are especially important for the delivery of an adequate amount of erythromycin to the site of periprosthetic inflammation and reducing local inflammation in a sustained manner.
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Authors | Wei Song, Xiaowei Yu, Sunxi Wang, Ralph Blasier, David C Markel, Guangzhao Mao, Tong Shi, Weiping Ren |
Journal | International journal of nanomedicine
(Int J Nanomedicine)
Vol. 6
Pg. 3173-86
( 2011)
ISSN: 1178-2013 [Electronic] New Zealand |
PMID | 22228990
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Cyclodextrins
- Nanocapsules
- Erythromycin
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Topics |
- Anti-Inflammatory Agents
(administration & dosage, chemistry)
- Apoptosis
(drug effects)
- Cell Line
- Cell Proliferation
(drug effects)
- Cyclodextrins
(administration & dosage, chemistry)
- Drug Therapy, Combination
(methods)
- Erythromycin
(administration & dosage, chemistry)
- Humans
- Nanocapsules
(administration & dosage, chemistry)
- Osteoblasts
(cytology, drug effects)
- Osteoclasts
(cytology, drug effects)
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