[Extensive Dowling-Degos disease following long term PUVA therapy].

Abstract

BACKGROUND:

Dowling-Degos disease is a rare and benign inherited dermatosis.

PATIENTS AND METHODS:

A 53-year-old woman presented with generalized histologically confirmed Dowling-Degos disease revealed 8 years after psoralen photochemotherapy (PUVA) for psoriasis. This presentation was special in terms of its considerable spread as well as the absence of comedone-like and punctate scars.

DISCUSSION:

Dowling-Degos disease is a reticulate pigmentary disorder of the flexures associating prominent comedone-like lesions and pitted scars. Diagnosis is based on clinical and histopathological examination, which allows this entity to be differentiated from other reticulate pigmentary disorders. A literature review failed to provide any indication that PUVA therapy either aggravates or reveals Dowling-Degos disease, a finding which we feel merits mention.

• Authors: R Kort Khaddar, W Koubaa Mahjoub, I Zaraa, M Ben Sassi, A Ben Osman, A Chadli Debbiche, M Mokni
• Journal: Annales de dermatologie et de venereologie (Ann Dermatol Venereol) Vol. 139 Issue 1 Pg. 54-7 (Jan 2012) ISSN: 0151-9638 [Print] France
• Vernacular Title: Maladie de Dowling-Degos étendue après PUVA thérapie prolongée.
• PMID: 22225744 (Publication Type: Case Reports, English Abstract, Journal Article)
• Copyright: Copyright © 2011 Elsevier Masson SAS. All rights reserved.

Chemical References

• KRT5 protein, human
• Keratin-5
• Acitretin

Topics

• Acitretin (therapeutic use)
• Genes, Dominant
• Humans
• Keratin-5 (genetics)
• Melanosis (complications, diagnosis, genetics, pathology)
• Melanosomes (pathology)
• Middle Aged
• PUVA Therapy (adverse effects)
• Penetrance
• Psoriasis (complications, drug therapy, pathology)
• Ultraviolet Rays (adverse effects)