Abstract | AIM: METHODS: RESULTS: SDA treatment of S37-bearing mice resulted in the reduced activities of total SOD, SOD isoforms (especially Mn-SOD), Cat, GP and significantly decreased GSH content on the background of LP intensification in tumor tissue. CONCLUSION: The observed changes of oxidative homeostasis in S37-bearing animals treated with SDA could be considered as an element of antitumor action of SDA.
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Authors | L V Sorokina, T V Pyatchanina, G V Didenko, A A Kaplia, S V Khyzhnyak |
Journal | Experimental oncology
(Exp Oncol)
Vol. 33
Issue 4
Pg. 216-21
(Dec 2011)
ISSN: 1812-9269 [Print] Ukraine |
PMID | 22217710
(Publication Type: Journal Article)
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Chemical References |
- Thiobarbituric Acid Reactive Substances
- Dichloroacetic Acid
- Catalase
- Glutathione Peroxidase
- Superoxide Dismutase
- Glutathione Reductase
- Glutathione
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Topics |
- Animals
- Catalase
(metabolism)
- Cell Proliferation
(drug effects)
- Dichloroacetic Acid
(administration & dosage, pharmacology)
- Glutathione
(metabolism)
- Glutathione Peroxidase
(metabolism)
- Glutathione Reductase
(metabolism)
- Injections, Intraperitoneal
- Male
- Mice
- Mice, Inbred BALB C
- Oxidation-Reduction
- Sarcoma 37
(drug therapy, metabolism, mortality)
- Superoxide Dismutase
(metabolism)
- Thiobarbituric Acid Reactive Substances
(metabolism)
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