Immunomodulatory and antioxidant effects of carboxymethylpachymaran on the mice infected with PCV2.

Abstract

The objective of the current study is to investigate the protective effect of carboxymethylpachymaran (CMP) on the immune system of mice via multiple infections with porcine circovirus type 2 (PCV2). The in vivo results showed that CMP administration significantly improved the spleen or thymus index, promoted the proliferation activities of T or B lymphocytes, and increased the production of glutathione, the superoxidase dismutase capacity, and the total antioxidant capacity in the spleen or thymus of PCV2-infected mice. The administration of different CMP doses to PVC2-inoculated mice resulted in the upregulation of IL-2 and IFN-α or the downregulation of IL-10 levels in the serum. These findings suggest that CMP has potential applications in regulating immunological functions to overcome the immunosuppresion caused by PCV2 infection in mice. The findings may also prove useful in designing effective therapies against PCV2 infection.

• Authors: Ying-Yi Wei, Ting-Jun Hu, Zi-Jie Su, Yun Zeng, Xiao-Jie Wei, Shu-Xia Zhang
• Journal: International journal of biological macromolecules (Int J Biol Macromol) Vol. 50 Issue 3 Pg. 713-9 (Apr 01 2012) ISSN: 1879-0003 [Electronic] Netherlands
• PMID: 22214825 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier B.V. All rights reserved.

Chemical References

• Antioxidants
• Cytokines
• Glucans
• Immunologic Factors
• carboxymethylpachymaran
• Superoxide Dismutase
• Glutathione

Topics

• Animals
• Antioxidants (pharmacology)
• Cell Line
• Cell Proliferation (drug effects)
• Circoviridae Infections (blood, enzymology, immunology, metabolism)
• Circovirus (pathogenicity)
• Cytokines (blood)
• Female
• Glucans (pharmacology)
• Glutathione (biosynthesis)
• Immune Tolerance (drug effects)
• Immunologic Factors (pharmacology)
• Lymphocytes (cytology, drug effects)
• Male
• Mice
• Spleen (cytology, drug effects, metabolism)
• Superoxide Dismutase (metabolism)
• Thymus Gland (cytology, drug effects, metabolism)