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Chronic hepatitis E in hematopoietic stem cell transplant patients in a low-endemic country?

Abstract
Cases of chronic hepatitis E have been described in patients after kidney and liver transplantation. In addition, hepatitis E virus (HEV) reactivation was reported after hematopoietic stem cell transplantation (HSCT). We here evaluated if HEV infection might explain elevated liver enzymes in a well selected cohort of allogeneic HSCT patients with biochemical evidence of hepatitis (n = 52). Of note, none of the subjects tested positive for HEV RNA, including 2 HSCT patients who had been infected with HEV already before transplantation. Thus, both chronic courses of HEV infections and HEV reactivations seem to be rather rare events in HSCT patients in a non-endemic country.
AuthorsC Koenecke, S Pischke, A Heim, L Raggub, B Bremer, R Raupach, S Buchholz, T Schulz, M P Manns, A Ganser, H Wedemeyer
JournalTransplant infectious disease : an official journal of the Transplantation Society (Transpl Infect Dis) Vol. 14 Issue 1 Pg. 103-6 (Feb 2012) ISSN: 1399-3062 [Electronic] Denmark
PMID22212560 (Publication Type: Journal Article)
Copyright© 2011 John Wiley & Sons A/S.
Chemical References
  • Alanine Transaminase
Topics
  • Adult
  • Aged
  • Alanine Transaminase (metabolism)
  • Chronic Disease (epidemiology)
  • Cohort Studies
  • Endemic Diseases
  • Female
  • Germany
  • Hematopoietic Stem Cell Transplantation (adverse effects)
  • Hepatitis E (epidemiology, virology)
  • Hepatitis E virus (isolation & purification)
  • Humans
  • Male
  • Middle Aged
  • Young Adult

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