[A case of complete response to interferon-α and S-1 combination therapy for multiple pulmonary recurrences of hepatocellular carcinoma after hepatic resection].

Abstract

A 77-year-old man was diagnosed as hepatocellular carcinoma, and was referred to our hospital. After he was treated by transcatheter chemoembolization, he underwent a left hepatic lobectomy of the liver and cholecystectomy. Serum AFP and PIVKA-II remarkably elevated 7 months after surgery, and CT scan revealed multiple metastatic nodules in bilateral lungs. The nodules were diagnosed as lung metastasis of HCC. Because the lesions grew larger, S-1/IFN was administered. Diagnostic imaging and tumor markers showed a marked improvement after 4 courses of S-1/IFN therapy, and he is still alive with good condition without recurrence and progression of tumors.

• Authors: Yoshiteru Katsura, Hiroshi Wada, Shogo Kobayashi, Shigeru Marubashi, Hidetoshi Eguchi, Masahiro Tanemura, Koji Umeshita, Kenichi Wakasa, Yuichiro Doki, Masaki Mori, Hiroaki Nagano
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 38 Issue 12 Pg. 2487-9 (Nov 2011) ISSN: 0385-0684 [Print] Japan
• PMID: 22202422 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Drug Combinations
• Interferon-alpha
• S 1 (combination)
• Tegafur
• Oxonic Acid

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma, Hepatocellular (drug therapy, pathology, therapy)
• Drug Combinations
• Embolization, Therapeutic
• Hepatectomy
• Humans
• Interferon-alpha (administration & dosage, therapeutic use)
• Liver Neoplasms (drug therapy, pathology, therapy)
• Lung Neoplasms (drug therapy, secondary)
• Male
• Oxonic Acid (administration & dosage, therapeutic use)
• Recurrence
• Remission Induction
• Tegafur (administration & dosage, therapeutic use)
• Tomography, X-Ray Computed