[A case of encephalopathy that was suspected to be caused by chemotherapy for colon cancer].

Abstract

We report a case of encephalopathy that was suspected to be caused by chemotherapy for liver metastasis from sigmoid colon cancer. A 72-year-old male was suspected that he had drug-induced eukoencephalopathy because he was presented with physical disorders during the FOLFOX/bevacizumab therapy. Although a brain MRI revealed Alzheimer disease, leukoencephalopathy was not excluded from the diagnoses due to a fact that his findings could not be compared before and after the chemotherapy. If leukoencephalopathy was suspected, chemotherapy should have been discontinued as soon as possible. Although a partial response was achieved, chemotherapy had to be discontinued in this case. The cases whose physical and neurological disorders were at risk due to a past history need an examination for nervous system in order to make a comparison with the findings before and after chemotherapy.

• Authors: Hideaki Ganno, Keiichi Fujiya, Masahiro Nakamura, Jun Takasaki, Yoshihisa Watayoh, Hidetoshi Amagasa, Toshiaki Kurokawa, Katsunori Ami, Akira Fukuda, Takeshi Nagahama, Masayuki Andoh, Kuniyoshi Arai
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 38 Issue 12 Pg. 2322-4 (Nov 2011) ISSN: 0385-0684 [Print] Japan
• PMID: 22202369 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Angiogenesis Inhibitors
• Antibodies, Monoclonal, Humanized
• Organoplatinum Compounds
• Bevacizumab
• Leucovorin
• Fluorouracil

Topics

• Aged
• Angiogenesis Inhibitors (adverse effects, therapeutic use)
• Antibodies, Monoclonal, Humanized (adverse effects, therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Bevacizumab
• Dementia (chemically induced)
• Fluorouracil (adverse effects, therapeutic use)
• Humans
• Leucovorin (adverse effects, therapeutic use)
• Liver Neoplasms (drug therapy, secondary)
• Male
• Organoplatinum Compounds (adverse effects, therapeutic use)
• Sigmoid Neoplasms (drug therapy, pathology, surgery)