[Preoperative chemoradiation (XELOX/RT) therapy for anal canal adenocarcinoma with the metastasis to inguinal lymph node].

Abstract

For a woman with poorly-differentiated anal canal adenocarcinoma in acknowledgment of metastasis to right inguinal lymph node, we gave radiotherapy combined with capecitabine as chemotherapy. Then the next two months, we performed XELOX therapy. Subsequently, we performed laparoscopic rectal amputation+D1 dissection+right groin lymph node dissection. The effect of preoperative chemoradiotherapy and pathological examination of the main tumor was Grade 2. And the right inguinal lymph node showed only a mucous persistence. Capecitabine was given as an adjuvant postoperative treatment and did not show a recurrence for five months after the operation. For a treatment for anal canal adenocarcinoma in acknowledgment of metastasis to inguinal lymph node, preoperative chemoradiotherapy may be effective.

• Authors: Shunichirou Makino, Yoshihito Ide, Kohei Murata
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 38 Issue 12 Pg. 2048-50 (Nov 2011) ISSN: 0385-0684 [Print] Japan
• PMID: 22202280 (Publication Type: Case Reports, Journal Article)

Chemical References

• Oxaloacetates
• Deoxycytidine
• Capecitabine
• Fluorouracil

Topics

• Adenocarcinoma (pathology, therapy)
• Anal Canal (pathology)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Anus Neoplasms (pathology, therapy)
• Capecitabine
• Chemoradiotherapy
• Deoxycytidine (analogs & derivatives, therapeutic use)
• Female
• Fluorouracil (analogs & derivatives, therapeutic use)
• Humans
• Inguinal Canal (pathology)
• Lymphatic Metastasis
• Middle Aged
• Oxaloacetates
• Tomography, X-Ray Computed