[Molecular mechanisms for the improvement of wound healing ability of periodontal ligament in Marfan's syndrome].

Abstract

Marfan's syndrome (MFS) is a systemic disorder of the connective tissues caused by insufficient fibrillin-1 microfibril formation and can cause cardiac complications, emphysema, ocular lens dislocation and severe periodontal disease. ADAMTSL6β, a microfibril-associated extracellular matrix protein that has been implicated in fibrillin-1 microfibril assembly is able to improve microfibril insufficiency in MFS mice model. These findings suggest a new therapeutic strategy for the treatment of MFS through ADAMTSL6β-mediated fibrillin-1 microfibril assembly. We here review effect on ADAMTSL6β to the improvement of microfibril insufficiency in periodontal tissue as a model.

• Authors: Masahiro Saito, Takashi Tsuji
• Journal: Clinical calcium (Clin Calcium) Vol. 22 Issue 1 Pg. 35-42 (Jan 2012) ISSN: 0917-5857 [Print] Japan
• PMID: 22201097 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Extracellular Matrix Proteins
• FBN1 protein, human
• Fbn1 protein, mouse
• Fibrillin-1
• Fibrillins
• Microfilament Proteins

Topics

• Animals
• Extracellular Matrix Proteins (physiology)
• Fibrillin-1
• Fibrillins
• Humans
• Marfan Syndrome (genetics, physiopathology, therapy)
• Mice
• Microfibrils (metabolism, physiology)
• Microfilament Proteins (physiology)
• Molecular Targeted Therapy
• Periodontal Ligament (physiopathology)
• Protein Multimerization
• Regeneration
• Wound Healing (genetics)