[Mannatide enhances the efficacy of fractionated and unfractionated radiotherapy in mice bearing Lewis lung cancer].

Abstract

OBJECTIVE:

To investigate the effect of mannatide injection (MI) in enhancing the efficacy of radiotherapy in two therapeutic schedules in mice bearing Lewis lung cancer.

METHODS:

C57BL/6 mice bearing Lewis lung cancer xenograft were assigned randomly into control group, fractionated schedule (FS) group, nonfractionated schedule (NFS) group, MI group, FS+MI group, and NFS+MI group (n=10). MI (4.5 mg/kg) or saline was given intraperitoneally for 14 consecutive days in the corresponding groups. Radiation with 8 MeV electron beam was delivered in a single 4 Gy dose in NFS and in 4 fractions (total dose 4 Gy) in FS. Tumor inhibition rate and the spleen and thymus index were calculated after the treatments.

RESULTS:

MI significantly enhanced the efficacy of radiotherapy with a tumor inhibition rate reaching 70% in FS+MI group (P<0.01). FS resulted in a significantly higher tumor inhibition rate than NFS (P<0.05), but the rates were comparable between FS+MI and NFS+MI groups. The spleen index and thymus indices were significantly higher in FS+MI and NFS+MI groups than in FS and NFS groups (P<0.05).

CONCLUSION:

MI can enhance the efficacy of radiotherapy with different therapeutic schedules in mice bear Lewis lung cancer, and MI plus fractionated radiation produces the optimal effect.

• Authors: Rui-tai Fan, Yong Hu, Jun-qi Liu, Jing-jing Zhang, Rui Song, Hao Gu
• Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao) Vol. 31 Issue 12 Pg. 2072-5 (Dec 2011) ISSN: 1673-4254 [Print] China
• PMID: 22200715 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biological Products
• Radiation-Sensitizing Agents

Topics

• Animals
• Biological Products (therapeutic use)
• Carcinoma, Lewis Lung (drug therapy, radiotherapy)
• Combined Modality Therapy
• Dose Fractionation, Radiation
• Dose-Response Relationship, Radiation
• Male
• Mice
• Mice, Inbred C57BL
• Neoplasm Transplantation
• Radiation-Sensitizing Agents (therapeutic use)
• Streptococcus