Abstract |
Eleven-nineteen lysine-rich leukemia (ELL) participates in the super elongation complex (SEC) with the RNA polymerase II (Pol II) CTD kinase P-TEFb. SEC is a key regulator in the expression of HOX genes in mixed lineage leukemia (MLL)-based hematological malignancies, in the control of induced gene expression early in development, and in immediate early gene transcription. Here, we identify an SEC-like complex in Drosophila, as well as a distinct ELL-containing complex that lacks P-TEFb and other components of SEC named the "little elongation complex" (LEC). LEC subunits are highly enriched at RNA Pol II-transcribed small nuclear RNA ( snRNA) genes, and the loss of LEC results in decreased snRNA expression in both flies and mammals. The specialization of the SEC and LEC complexes for mRNA and snRNA-containing genes, respectively, suggests the presence of specific classes of elongation factors for each class of genes transcribed by RNA polymerase II.
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Authors | Edwin R Smith, Chengqi Lin, Alexander S Garrett, Janet Thornton, Nima Mohaghegh, Deqing Hu, Jessica Jackson, Anita Saraf, Selene K Swanson, Christopher Seidel, Laurence Florens, Michael P Washburn, Joel C Eissenberg, Ali Shilatifard |
Journal | Molecular cell
(Mol Cell)
Vol. 44
Issue 6
Pg. 954-65
(Dec 23 2011)
ISSN: 1097-4164 [Electronic] United States |
PMID | 22195968
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
- Multiprotein Complexes
- RNA, Small Nuclear
- Transcriptional Elongation Factors
- Positive Transcriptional Elongation Factor B
- RNA Polymerase II
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Topics |
- Animals
- Drosophila
- Multiprotein Complexes
(metabolism)
- Positive Transcriptional Elongation Factor B
(metabolism)
- RNA Polymerase II
(metabolism)
- RNA, Small Nuclear
(genetics)
- Rats
- Transcription, Genetic
(genetics)
- Transcriptional Elongation Factors
(metabolism)
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