Dysembryoplastic neuroepithelial tumor-like neoplasm of the septum pellucidum: review of 2 cases with chromosome 1p/19q and IDH1 analysis.

Abstract

Dysembryoplastic neuroepithelial tumor (DNT)-like neoplasms of the septum pellucidum are extremely rare. We reviewed 2 cases of DNT-like neoplasm of the septum pellucidum and specifically studied the immunohistochemical features and chromosomes 1p and 19q deletions. One case was a 26-year-old woman who complained of aggravated headache for 2 weeks. The other case was a 31-year-old female presenting with double vision for a month. Histological examinations showed that the lesions were composed of uniform oligodendrocytelike cells (OLCs) with obvious floating neurons in a mucin-rich background. Immunohistochemical studies revealed that both tumors were diffusely positive for Synaptophysin and Olig2. Sporadic neurons were clearly positive for NeuN. Loss of chromosome 1p/19q and isocitrate dehydrogenase 1(IDH1) mutations were not identified in both cases. It might indicate that these OLCs of DNT-like neoplasms were genetically different from glial tumors, although they showed close morphological similarities.

• Authors: Ji Xiong, Ying Liu, Shu-Guang Chu, Hong Chen, Hai-Xia Chen, Ying Mao, Yin Wang
• Journal: Clinical neuropathology (Clin Neuropathol) 2012 Jan-Feb Vol. 31 Issue 1 Pg. 31-8 ISSN: 0722-5091 [Print] Germany
• PMID: 22192702 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Isocitrate Dehydrogenase
• IDH1 protein, human

Topics

• Adult
• Brain Neoplasms (genetics, pathology)
• Chromosomes, Human, Pair 1 (genetics)
• Chromosomes, Human, Pair 19 (genetics)
• Female
• Humans
• Immunohistochemistry
• In Situ Hybridization, Fluorescence
• Isocitrate Dehydrogenase (genetics)
• Mutation
• Neoplasms, Neuroepithelial (genetics, pathology)
• Septum Pellucidum (pathology)