Abstract | OBJECTIVES: METHODS: Athymic nude mice were infected with 2 × 10(7) cfu of a clinical isolate of C. carrionii. When typical lesions were established, treatments with posaconazole at 20 mg/kg/day, voriconazole at 20 mg/kg/day, itraconazole at 50 mg/kg/day or terbinafine at 250 mg/kg/day were initiated. Treatment efficacy was evaluated for 4 months by measuring the size of the lesions, observing any histopathological changes and culturing the excised tissue. RESULTS: CONCLUSIONS:
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Authors | Enrique Calvo, F Javier Pastor, Valentina Salas, Emilio Mayayo, Javier Capilla, Josep Guarro |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 67
Issue 3
Pg. 666-70
(Mar 2012)
ISSN: 1460-2091 [Electronic] England |
PMID | 22190608
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Antifungal Agents
(administration & dosage)
- Ascomycota
(drug effects, pathogenicity)
- Chromoblastomycosis
(microbiology, pathology)
- Disease Models, Animal
- Male
- Mice
- Mice, Nude
- Treatment Outcome
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