ANCA-associated glomerulonephritis in systemic-onset juvenile idiopathic arthritis.

Abstract

Systemic-onset juvenile idiopathic arthritis is an inflammatory disease of unknown cause and is not commonly associated with kidney involvement. We describe 3 patients with systemic-onset juvenile idiopathic arthritis with high disease activity who developed antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis 1-6 years after the onset of systemic-onset juvenile idiopathic arthritis. Renal and systemic-onset juvenile idiopathic arthritis remission occurred in one patient under anti-interleukin 1 (anti-IL-1) treatment associated with immunosuppressive drugs. The other 2 patients developed end-stage renal disease, and one of those patients died. This report suggests that the diagnosis of ANCA-associated glomerulonephritis must be considered in patients with systemic-onset juvenile idiopathic arthritis with persistently active systemic disease who present with proteinuria. Furthermore, use of an anti-IL-1 agent might be an effective therapeutic option.

• Authors: Alexandre Belot, Brigitte Bader-Meunier, Patrick Niaudet, Rémi Salomon, Anne-Marie Prieur, Laure-Hélène Noel, Pierre Quartier
• Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation (Am J Kidney Dis) Vol. 59 Issue 3 Pg. 439-43 (Mar 2012) ISSN: 1523-6838 [Electronic] United States
• PMID: 22189036 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2012 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Chemical References

• Antibodies, Antineutrophil Cytoplasmic

Topics

• Antibodies, Antineutrophil Cytoplasmic
• Arthritis, Juvenile (complications)
• Child, Preschool
• Female
• Glomerulonephritis (complications, immunology)
• Humans
• Infant
• Male