[Efficacy of topiramate for relapsed epileptic spasms with tuberous sclerosis: report of three cases].

Abstract

Topiramate (TPM) has been shown to be effective for epileptic spasms (ES) in children, but there is little clinical experience with TPM use in Japan. We report three tuberous sclerosis (TS) patients with relapsed ES, who became spasm-free while receiving TPM treatment. All three patients were treated with a starting dose of 0.5 mg/kg/day. The dosage was increased by 0.5 mg/kg/day every 2 weeks. Although the dose of TPM and the period until the relapsed ES subsided differed among these patients, spasm frequency was clearly reduced by a 1 mg/kg/day dose of TPM. Therefore, efficacy against relapsed ES appeared within one month in all three patients. All three became spasm-free, and there have been no ES relapses for more than 5 months to date. In case 2, seizures were well controlled by TPM alone. Cases 2 and 3 were able to discontinue zonisamide treatment. No adverse effects occurred in any of these patients.

• Authors: Shohei Nomura, Shuichi Shimakawa, Takuya Tanabe, Miho Fukui, Mitsuru Kashiwagi, Hiroshi Tamai
• Journal: No to hattatsu = Brain and development (No To Hattatsu) Vol. 43 Issue 6 Pg. 476-81 (Nov 2011) ISSN: 0029-0831 [Print] Japan
• PMID: 22180964 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticonvulsants
• Topiramate
• Fructose

Topics

• Adolescent
• Anticonvulsants (administration & dosage)
• Drug Administration Schedule
• Epilepsy (drug therapy, etiology)
• Female
• Fructose (administration & dosage, analogs & derivatives)
• Humans
• Infant
• Male
• Recurrence
• Topiramate
• Treatment Outcome
• Tuberous Sclerosis (complications)