Abstract | STUDY OBJECTIVES: PATIENTS: MEASUREMENTS AND RESULTS: Body mass index (BMI), serum leptin, and HbA1C were measured in patients and controls; and CSF hypocretin 1 and leptin measured in all patients. Female and male patients with narcolepsy and hypocretin deficiency had the highest mean BMI (27.8 and 26.2, respectively), not statistically different from patients with narcolepsy and normal hypocretin or controls, but statistically higher than the patients with idiopathic hypersomnia (p < 0.001 and 0.011, respectively). The number of obese patients (BMI > 30) was increased in both narcolepsy groups. Serum and CSF leptin levels correlated positively to BMI in patients and controls, but not to CSF hypocretin concentrations. HbA1C was within normal levels and similar in all groups. CONCLUSIONS:
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Authors | Mona S Heier, Tine S Jansson, Kaare M Gautvik |
Journal | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
(J Clin Sleep Med)
Vol. 7
Issue 6
Pg. 653-8
(Dec 15 2011)
ISSN: 1550-9397 [Electronic] United States |
PMID | 22171205
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- HCRT protein, human
- Intracellular Signaling Peptides and Proteins
- Leptin
- Neuropeptides
- Orexins
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Topics |
- Adult
- Aged
- Body Mass Index
- Case-Control Studies
- Cataplexy
(diagnosis, epidemiology)
- Causality
- Comorbidity
- Female
- Humans
- Idiopathic Hypersomnia
(diagnosis, epidemiology)
- Intracellular Signaling Peptides and Proteins
(cerebrospinal fluid, deficiency, metabolism)
- Leptin
(blood, cerebrospinal fluid)
- Male
- Metabolic Syndrome
(diagnosis, epidemiology)
- Middle Aged
- Narcolepsy
(diagnosis, epidemiology)
- Neuropeptides
(cerebrospinal fluid, deficiency, metabolism)
- Obesity
(diagnosis, epidemiology)
- Orexins
- Overweight
(diagnosis, epidemiology)
- Prognosis
- Reference Values
- Risk Assessment
- Severity of Illness Index
- Statistics, Nonparametric
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