HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Comparison of efficacy and safety of leptin replacement therapy in moderately and severely hypoleptinemic patients with familial partial lipodystrophy of the Dunnigan variety.

AbstractCONTEXT:
Leptin replacement therapy improves metabolic complications in patients with lipodystrophy and severe hypoleptinemia (SH), but whether the response is related to the degree of hypoleptinemia remains unclear.
OBJECTIVE:
The aim of the study was to compare efficacy of leptin therapy in familial partial lipodystrophy, Dunnigan variety (FPLD) patients with SH (serum leptin<7th percentile of normal) vs. those with moderate hypoleptinemia (MH; serum leptin in 7th to 20th percentiles).
DESIGN, SETTING, AND PATIENTS:
We conducted an open-label, parallel group, observational study in 14 SH (mean±sd, serum leptin, 1.9±1.1 ng/ml) and 10 MH (serum leptin, 5.3±1.0 ng/ml) women with FPLD.
INTERVENTION:
Patients received 0.08 mg/kg·d of metreleptin by twice daily sc injections for 6 months.
MAIN OUTCOME MEASURES:
The primary outcome variable was change in fasting serum triglycerides. Other secondary variables were fasting plasma glucose and insulin, insulin sensitivity, hemoglobin A1c, and hepatic triglyceride content.
RESULTS:
Median fasting serum triglycerides decreased from 228 to 183 mg/dl in the SH group (P=0.04) and from 423 to 339 mg/dl in the MH group (P=0.02), but with no difference between the groups (P value for interaction=0.96). Hepatic triglyceride levels similarly declined significantly from 8.8 to 4.9% in the SH group and from 23.7 to 9.2% in the MH group (P value for interaction=0.9). Loss of body weight and body fat occurred in both groups. Fasting glucose, insulin, glucose tolerance, and hemoglobin A1c levels did not change. K value on insulin tolerance test improved slightly in the SH group (0.98 to 1.24%; P=0.01), but not in the MH group (1.1 to 1.27%; P=0.4).
CONCLUSION:
Metreleptin replacement therapy is equally effective in FPLD patients with both SH and MH in reducing serum and hepatic triglyceride levels, but did not improve hyperglycemia.
AuthorsVinaya Simha, Lalitha Subramanyam, Lidia Szczepaniak, Claudia Quittner, Beverley Adams-Huet, Peter Snell, Abhimanyu Garg
JournalThe Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 97 Issue 3 Pg. 785-92 (Mar 2012) ISSN: 1945-7197 [Electronic] United States
PMID22170723 (Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Blood Glucose
  • Insulin
  • Leptin
  • Lipids
  • metreleptin
Topics
  • Adipose Tissue (drug effects, metabolism)
  • Adult
  • Aged
  • Blood Glucose (metabolism)
  • Body Weight (drug effects)
  • Energy Metabolism (drug effects)
  • Female
  • Hormone Replacement Therapy (adverse effects)
  • Humans
  • Insulin (blood)
  • Leptin (administration & dosage, adverse effects, analogs & derivatives, deficiency, therapeutic use)
  • Lipids (blood)
  • Lipodystrophy, Familial Partial (drug therapy, metabolism)
  • Middle Aged
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: