Abstract | CONTEXT:
Leptin replacement therapy improves metabolic complications in patients with lipodystrophy and severe hypoleptinemia (SH), but whether the response is related to the degree of hypoleptinemia remains unclear. OBJECTIVE: DESIGN, SETTING, AND PATIENTS: We conducted an open-label, parallel group, observational study in 14 SH (mean±sd, serum leptin, 1.9±1.1 ng/ml) and 10 MH (serum leptin, 5.3±1.0 ng/ml) women with FPLD. INTERVENTION: MAIN OUTCOME MEASURES: RESULTS: Median fasting serum triglycerides decreased from 228 to 183 mg/dl in the SH group (P=0.04) and from 423 to 339 mg/dl in the MH group (P=0.02), but with no difference between the groups (P value for interaction=0.96). Hepatic triglyceride levels similarly declined significantly from 8.8 to 4.9% in the SH group and from 23.7 to 9.2% in the MH group (P value for interaction=0.9). Loss of body weight and body fat occurred in both groups. Fasting glucose, insulin, glucose tolerance, and hemoglobin A1c levels did not change. K value on insulin tolerance test improved slightly in the SH group (0.98 to 1.24%; P=0.01), but not in the MH group (1.1 to 1.27%; P=0.4). CONCLUSION:
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Authors | Vinaya Simha, Lalitha Subramanyam, Lidia Szczepaniak, Claudia Quittner, Beverley Adams-Huet, Peter Snell, Abhimanyu Garg |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 97
Issue 3
Pg. 785-92
(Mar 2012)
ISSN: 1945-7197 [Electronic] United States |
PMID | 22170723
(Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Insulin
- Leptin
- Lipids
- metreleptin
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Topics |
- Adipose Tissue
(drug effects, metabolism)
- Adult
- Aged
- Blood Glucose
(metabolism)
- Body Weight
(drug effects)
- Energy Metabolism
(drug effects)
- Female
- Hormone Replacement Therapy
(adverse effects)
- Humans
- Insulin
(blood)
- Leptin
(administration & dosage, adverse effects, analogs & derivatives, deficiency, therapeutic use)
- Lipids
(blood)
- Lipodystrophy, Familial Partial
(drug therapy, metabolism)
- Middle Aged
- Treatment Outcome
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